Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SLC22A1 | O15245 | 1/20 | 0.35 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.34 |
| ▸ | ADRB1 | P08588 | 2/20 | 0.34 |
| ▸ | ADRB3 | P13945 | 2/20 | 0.34 |
| ▸ | PRKCA | P17252 | 4/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16647588 | 0.89 | ALDH1A1 (0.39) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL16644554 | 0.89 | ALDH1A1 (0.39) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL17860796 | 0.77 | ALDH1A1 (0.41) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL17863956 | 0.75 | ALDH1A1 (0.47) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL16644528 | 0.74 | ALDH1A1 (0.39) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL20227073 | 0.73 | ALDH1A1 (0.40) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL18879964 | 0.73 | GAA (0.36) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL16644530 | 0.72 | ALDH1A1 (0.36) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL17359539 | 0.72 | ALDH1A1 (0.36) | ALDH1A1LMNATDP1TSHRMAPK1 | |
| SCHEMBL18877385 | 0.71 | ALDH1A1 (0.40) | ALDH1A1LMNATDP1TSHRMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10370401-B2 | Substituted nucleosides, nucleotides and analogs thereof | Janssen Biopharma, Inc. (US) | 2019-08-06 | — | — | US | disclosed |
| US-20180044369-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | Janssen Biopharma, Inc. | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044369-A1 | SUBSTITUTED NUCLEOSIDES, NUCLEOTIDES AND ANALOGS THEREOF | PNP, NT5C3B, NUDT1 | ALDH1A1 2525/4885LMNA 1060/4885TDP1 367/4885 |
| US-10370401-B2 | Substituted nucleosides, nucleotides and analogs thereof | PNP, NT5C3B, NUDT1 | ALDH1A1 2525/4885LMNA 1060/4885TDP1 367/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.