Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 10/20 | 0.46 |
| ▸ | MAPK13 | O15264 | 8/20 | 0.46 |
| ▸ | MAPK12 | P53778 | 8/20 | 0.46 |
| ▸ | MAPK11 | Q15759 | 8/20 | 0.46 |
| ▸ | BRAF | P15056 | 2/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 4/20 | 0.45 |
| ▸ | GCGR | P47871 | 5/20 | 0.45 |
| ▸ | RAF1 | P04049 | 3/20 | 0.43 |
| ▸ | MAPK9 | P45984 | 2/20 | 0.43 |
| ▸ | CSNK1D | P48730 | 2/20 | 0.43 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | FRK | P42685 | 1/20 | 0.43 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.43 |
| ▸ | GSK3B | P49841 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.43 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19868929 | 0.82 | MAPK13 (0.71) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL19857273 | 0.81 | MAPK11 (0.73) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL19869000 | 0.81 | MAPK13 (0.73) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL19868996 | 0.81 | MAPK14 (0.67) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL19868999 | 0.79 | MAPK13 (0.68) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL19868980 | 0.78 | MAPK14 (0.59) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL9196324 | 0.78 | MAPK11 (0.69) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL19868944 | 0.78 | MAPK14 (0.62) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL19868998 | 0.77 | ALOX5 (0.70) | MAPK14MAPK13MAPK12MAPK11BRAF | |
| SCHEMBL12591976 | 0.77 | S1PR1 (0.54) | GSK3BS1PR1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180044316-A1 | POTENTIATORS OF BETA-LACTAM ANTIBIOTICS | UNIVERSITY OF NOTRE DAME DU LAC (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044316-A1 | POTENTIATORS OF BETA-LACTAM ANTIBIOTICS | CREB1, PPP6R1, PPP1R10 | MAPK14 440/4885MAPK13 782/4885MAPK12 363/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.