Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | LMNA | P02545 | 2/20 | 0.65 |
| ▸ | POLB | P06746 | 1/20 | 0.65 |
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | TGM2 | P21980 | 9/20 | 0.58 |
| ▸ | F13A1 | P00488 | 8/20 | 0.58 |
| ▸ | TGM1 | P22735 | 5/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TGM3 | Q08188 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19869960 | 0.85 | TGM2 (0.65) | GAALMNAPOLBTSHRTGM2 | |
| SCHEMBL16013381 | 0.85 | GAA (0.65) | GAALMNAPOLBTSHRTGM2 | |
| SCHEMBL19869948 | 0.79 | TSHR (0.76) | GAALMNAPOLBTSHRMAPT | |
| SCHEMBL2512179 | 0.78 | TGM2 (0.55) | TGM2F13A1TGM1TGM3ALDH1A1 | |
| SCHEMBL10042199 | 0.77 | EPHX2 (0.53) | GAATGM2F13A1TGM1MAPT | |
| SCHEMBL5440864 | 0.77 | TGM2 (0.57) | TGM2F13A1TGM1TGM3ALDH1A1 | |
| SCHEMBL19869951 | 0.76 | PKM (0.47) | LMNAPOLBTSHRALDH1A1 | |
| SCHEMBL19869959 | 0.76 | BRD4 (0.47) | GAALMNAPOLBTSHRTGM2 | |
| SCHEMBL31399732 | 0.75 | ALDH1A1 (0.65) | GAALMNATSHRTGM2F13A1 | |
| SCHEMBL2818818 | 0.75 | TGM2 (0.50) | GAAPOLBTGM2F13A1TGM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3265453-B1 | NEW PYRIDINONES AND ISOQUINOLINONES AS INHIBITORS OF THE BROMODOMAIN BRD9 | BOEHRINGER INGELHEIM INT (DE) | 2022-06-29 | — | — | EP | disclosed |
| US-11319318-B2 | Pyridinones and isoquinolinones as inhibitors of the bromodomain BRD9 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2022-05-03 | — | — | US | disclosed |
| US-20180044335-A1 | New Pyridinones and Isoquinolinones as Inhibitors of the Bromodomain BRD9 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-02-15 | — | — | US | disclosed |
| US-20180044335-A1 | New Pyridinones and Isoquinolinones as Inhibitors of the Bromodomain BRD9 | BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180044335-A1 | New Pyridinones and Isoquinolinones as Inhibitors of the Bromodomain BRD9 | BRD9, BRD1, BRD2 | GAA 4237/4885LMNA 1902/4885POLB 914/4885 |
| US-11319318-B2 | Pyridinones and isoquinolinones as inhibitors of the bromodomain BRD9 | BRD9, BRD1, BRD2 | GAA 4152/4885LMNA 1745/4885POLB 958/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.