Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 4/20 | 0.69 |
| ▸ | AKT1 | P31749 | 2/20 | 0.69 |
| ▸ | MAPT | P10636 | 4/20 | 0.50 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | NFKB1 | P19838 | 5/20 | 0.49 |
| ▸ | NFKB2 | Q00653 | 5/20 | 0.49 |
| ▸ | RELA | Q04206 | 5/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 5/20 | 0.47 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1986242 | 0.92 | ROCK2 (0.69) | ROCK2AKT1MAPTROCK1HPGD | |
| SCHEMBL1988576 | 0.83 | ROCK2 (0.59) | ROCK2AKT1MAPTROCK1HPGD | |
| SCHEMBL1987882 | 0.83 | ROCK2 (0.79) | ROCK2AKT1MAPTROCK1HPGD | |
| SCHEMBL1986233 | 0.82 | ROCK2 (1.00) | ROCK2AKT1MAPTROCK1HPGD | |
| SCHEMBL1988406 | 0.82 | ROCK2 (1.00) | ROCK2AKT1MAPTROCK1HPGD | |
| SCHEMBL1987101 | 0.82 | NFKB1 (0.60) | ROCK2AKT1MAPTROCK1NFKB1 | |
| SCHEMBL1988342 | 0.71 | ROCK2 (0.77) | ROCK2AKT1MAPTROCK1HPGD | |
| SCHEMBL1992425 | 0.70 | ROCK2 (0.76) | ROCK2AKT1MAPTROCK1HPGD | |
| SCHEMBL12603087 | 0.70 | ROCK2 (0.72) | ROCK2AKT1MAPTROCK1HPGD | |
| SCHEMBL12602422 | 0.69 | ROCK2 (0.74) | ROCK2AKT1MAPTROCK1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2011-06-23 | — | — | US | disclosed |
| WO-2009079008-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | FENG YANGBO (US) | 2009-06-25 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110150833-A1 | BENZOPYRANS AND ANALOGS AS RHO KINASE INHIBITORS | ROCK1, RHOA, RHOT2 | ROCK2 4/4885AKT1 31/4885MAPT 3442/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.