Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.56 |
| ▸ | TSHR | P16473 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.54 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | HTR1A | P08908 | 1/20 | 0.54 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.54 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.54 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.54 |
| ▸ | DRD1 | P21728 | 1/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.54 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18938268 | 0.82 | TDP1 (0.64) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL23789618 | 0.81 | ALDH1A1 (0.52) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL19870486 | 0.78 | CYP1A2 (0.71) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL13953865 | 0.78 | KMT2A (0.69) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL21688539 | 0.77 | HTT (0.53) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL21505040 | 0.76 | TDP1 (0.46) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL21505038 | 0.75 | ALDH1A1 (0.51) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL18074878 | 0.75 | CYP1A2 (0.63) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL4433592 | 0.74 | CYP1A2 (0.56) | ALDH1A1MAPK1ALOX15HSD17B10TSHR | |
| SCHEMBL21814399 | 0.74 | ALDH1A1 (0.51) | ALDH1A1MAPK1ALOX15HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180042932-A1 | COMBINATION OF BRIMONIDINE AND TIMOLOL FOR TOPICAL OPHTHALMIC USE | ALLERGAN SALES LLC (US) | 2018-02-15 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180042932-A1 | COMBINATION OF BRIMONIDINE AND TIMOLOL FOR TOPICAL OPHTHALMIC USE | ADRB2, ADRA2B, PDE3B | ALDH1A1 2506/4885MAPK1 3538/4885ALOX15 1745/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.