Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21268021 | 0.80 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| SCHEMBL2309241 | 0.70 | ALDH1A1 (0.50) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| SCHEMBL2631833 | 0.69 | ALDH1A1 (0.48) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| SCHEMBL9132333 | 0.69 | ALDH1A1 (0.44) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| Bromide SCHEMBL29136390 | 0.69 | ALDH1A1 (0.49) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| SCHEMBL29791776 | 0.67 | ALDH1A1 (0.59) | ALDH1A1KDM4EHSD17B10POLBMEN1 | |
| SCHEMBL9910017 | 0.67 | ALDH1A1 (0.46) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| SCHEMBL228037 | 0.66 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| SCHEMBL2668143 | 0.66 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10LMNAMAPT | |
| SCHEMBL15314186 | 0.66 | ALDH1A1 (0.53) | ALDH1A1KDM4EHSD17B10LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3284743-B1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI HUILUN LIFE SCIENCE & TECH CO LTD (CN) | 2022-07-06 | — | — | EP | disclosed |
| US-10174023-B2 | Heterocyclic-imidazole compounds, pharmaceutical compositions thereof, preparation method therefor and use thereof | SHANGHAI HUILUN LIFE SCIENCE & TECHNOLOGY CO., LTD (CN) | 2019-01-08 | — | — | US | disclosed |
| US-20180111927-A1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | SHANGHAI HUILUN LIFE SCIENCE & TECHNOLOGY CO., LTD (CN) | 2018-04-26 | — | — | US | disclosed |
| EP-3284743-A1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | Shanghai Huilun Life Science & Technology Co., Ltd (CN) | 2018-02-21 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180111927-A1 | HETEROCYCLIC-IMIDAZOLE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, PREPARATION METHOD THEREFOR AND USE THEREOF | PARP1, PARP8, PARP11 | ALDH1A1 316/4885KDM4E 1873/4885HSD17B10 2034/4885 |
| US-10174023-B2 | Heterocyclic-imidazole compounds, pharmaceutical compositions thereof, preparation method therefor and use thereof | PARP1, PARP8, PARP11 | ALDH1A1 316/4885KDM4E 1873/4885HSD17B10 2034/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.