SCHEMBL228037

SCHEMBL228037

O=C1OC(O)c2ccccc21

nearest known ligand 0.53

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.53
HSD17B10 Q99714 2/20 0.42
GAA P10253 1/20 0.41
KDM4E B2RXH2 1/20 0.41
LMNA P02545 2/20 0.40
MEN1 O00255 2/20 0.40
KMT2A Q03164 2/20 0.40
CYP1A2 P05177 1/20 0.40
CYP3A4 P08684 1/20 0.40
MAPT P10636 1/20 0.40
CYP2C9 P11712 1/20 0.40
HPGD P15428 1/20 0.40
CYP2C19 P33261 1/20 0.40
RECQL P46063 1/20 0.40
POLB P06746 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15314185 1.00 ALDH1A1 (0.53) ALDH1A1HSD17B10GAAKDM4ELMNA
SCHEMBL31315628 1.00 ALDH1A1 (0.53) ALDH1A1HSD17B10GAAKDM4ELMNA
SCHEMBL18705376 1.00 ALDH1A1 (0.53) ALDH1A1HSD17B10GAAKDM4ELMNA
SCHEMBL29791776 0.78 ALDH1A1 (0.59) ALDH1A1HSD17B10GAAKDM4EMEN1
SCHEMBL17769033 0.78 TYMS (0.48) ALDH1A1HSD17B10KDM4EMEN1KMT2A
SCHEMBL21881721 0.77 APEX1 (0.38) ALDH1A1GAAKDM4ELMNAMEN1
SCHEMBL11109865 0.76 MAOB (0.45) ALDH1A1HSD17B10KDM4E
SCHEMBL18705354 0.76 MAOA (0.35) ALDH1A1HSD17B10KDM4EMEN1KMT2A
SCHEMBL23771080 0.75 POLB (0.39) ALDH1A1HSD17B10GAAKDM4EMEN1
SCHEMBL31084351 0.75 POLB (0.39) ALDH1A1HSD17B10GAAKDM4EMEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 566 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-115724824-B 3- (amidoalkylthio) phthalide compound, preparation method and application thereof 四川大学 2024-03-15 CN claimed
CN-115724824-A 3- (amidoalkylthio) phthalide compound, preparation method and application thereof 四川大学 2023-03-03 CN claimed
CN-108794405-B Method for continuously preparing Olaparib intermediate by adopting micro-channel modular reaction device 南京工业大学 2020-09-04 CN claimed
EP-2203783-A2 THICK FILM RESISTS AZ Electronic Materials USA Corp. (US) 2010-07-07 EP claimed
US-7566707-B2 Imidazopyridazinone and imidazopyridone derivatives, the preparation thereof and their use as pharmaceutical compositions BOEHRINGER INGELHEIM INTERNATIONAL GMBH (DE) 2009-07-28 US claimed
WO-2009040661-A2 THICK FILM RESISTS AZ ELECTRONIC MATERIALS USA CORP. (DE) 2009-04-02 WO claimed
US-20090081589-A1 THICK FILM RESISTS MERCK PATENT GMBH (DE) 2009-03-26 US claimed
US-20090022686-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2009-01-22 US claimed
EP-1517687-B1 MEDICAMENT FOR THE TREATMENT OF THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME BOEHRINGER INGELHEIM PHARMA (DE) 2007-06-20 EP claimed
EP-1562903-A4 MUCIN SYNTHESIS INHIBITORS GENAERA CORP (US) 2006-09-20 EP claimed
WO-2004000310-A1 MEDICAMENT FOR THE TREATMENT OF THE SYSTEMIC INFLAMMATORY RESPONSE SYNDROME BOEHRINGER INGELHEIM PHARMA GMBH & CO. KG (DE) 2003-12-31 WO claimed
US-20030236220-A1 MUCIN SYNTHESIS INHIBITORS GENAERA CORPORATION (US) 2003-12-25 US claimed
US-6593355-B2 2-phenylaminomethyl benzimidazole derivatives BOEHRINGER INGELEHIM PHARMA KG (DE) 2003-07-15 US claimed
US-20030004356-A1 Benzimidazoles with antithrombotic activity BOEHRINGER INGELHEIM PHARMA KG (DE) 2003-01-02 US claimed
EP-1095025-B1 BENZIMIDAZOLES, PRODUCTION THEREOF AND USE THEREOF AS MEDICAMENTS BOEHRINGER INGELHEIM PHARMA (DE) 2002-12-11 EP claimed
EP-0443533-B1 Positive photoresist composition FUJI PHOTO FILM CO LTD (JP) 1998-09-30 EP claimed
EP-0443533-A2 Positive photoresist composition FUJI PHOTO FILM CO., LTD. (JP) 1991-08-28 EP claimed
EP-0427031-A2 N-aryl-nitrogen heterocycles BAYER AG (DE) 1991-05-15 EP claimed
EP-0061765-A1 Beta-Lactams E.R. SQUIBB & SONS, INC. (US) 1982-10-06 EP claimed
US-4213969-A Phosphonous acid derivatives, processes for their preparation and their use in combatting microorganisms CIBA-GEIGY CORPORATION (US) 1980-07-22 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090022686-A1 PHARMACEUTICAL COMPOSITIONS FOR THE TREATMENT OF SYSTEMIC INFLAMMATORY RESPONSE SYNDROME IL5, TSLP, TLR5 ALDH1A1 1668/4885HSD17B10 1662/4885GAA 1783/4885
US-20030236220-A1 MUCIN SYNTHESIS INHIBITORS MUC1, CFTR, SERPINB1 ALDH1A1 1261/4885HSD17B10 2176/4885GAA 210/4885
US-20030004356-A1 Benzimidazoles with antithrombotic activity SERPINC1, SERPINB1, PF4 ALDH1A1 232/4885HSD17B10 4035/4885GAA 2286/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.