Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.35 |
| ▸ | ACP1 | P24666 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | VNN1 | O95497 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 2/20 | 0.34 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.34 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.33 |
| ▸ | DRD2 | P14416 | 1/20 | 0.32 |
| ▸ | DRD3 | P35462 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873479 | 0.88 | ACP1 (0.45) | ACP1CHRM3DRD2DRD3 | |
| SCHEMBL16928197 | 0.86 | SIGMAR1 (0.40) | TRPV1KAT2BLMNACHRM3MALT1 | |
| SCHEMBL16928527 | 0.78 | ACP1 (0.56) | ACP1CHRM3 | |
| SCHEMBL19873466 | 0.78 | CAMK2D (0.35) | ACP1CHRM3DRD2DRD3 | |
| SCHEMBL16928187 | 0.78 | ACP1 (0.43) | ACP1DRD2MEN1ALDH1A1KMT2A | |
| SCHEMBL16928147 | 0.77 | CHRNB2 (0.42) | MALT1ALDH1A1 | |
| SCHEMBL17721585 | 0.77 | PIM2 (0.46) | MEN1ALDH1A1KMT2A | |
| SCHEMBL16928205 | 0.77 | NMT1 (0.51) | ACP1CHRM3MEN1KMT2A | |
| SCHEMBL16928011 | 0.76 | ACP1 (0.48) | ACP1CHRM3DRD2DRD3 | |
| SCHEMBL16928101 | 0.75 | ACP1 (0.43) | ACP1DRD2DRD3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3351538-A1 | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS | The United States of America, as represented by The Secretary of The Army, on behalf of Walter Reed Army Institute of Research (US) | 2018-07-25 | — | — | EP | disclosed |
| EP-2970153-B1 | TRIAZINE COMPOUNDS AND COMPOSITIONS THEREOF AND METHODS FOR TREATING MALARIA AND CHEMOPROPHYLAXIS | THE US SECRETARY OF THE ARMY ON BEHALF OF WALTER REED ARMY INSTITUTE OF RESEARCH (US) | 2018-02-21 | — | — | EP | disclosed |