Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 1/20 | 0.38 |
| ▸ | LPAR3 | Q9UBY5 | 1/20 | 0.38 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.32 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.32 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.32 |
| ▸ | HDAC2 | Q92769 | 4/20 | 0.31 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.31 |
| ▸ | BRD2 | P25440 | 1/20 | 0.31 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.30 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.30 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.30 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.30 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873634 | 1.00 | LPAR1 (0.38) | LPAR1LPAR3NAAASLC6A2SLC6A4 | |
| SCHEMBL19873600 | 0.90 | LPAR1 (0.37) | LPAR1LPAR3NAAASLC6A2SLC6A4 | |
| SCHEMBL19873559 | 0.90 | LPAR1 (0.37) | LPAR1LPAR3NAAASLC6A2SLC6A4 | |
| SCHEMBL19873652 | 0.90 | LPAR1 (0.36) | LPAR1LPAR3NAAAENPP2 | |
| SCHEMBL19873555 | 0.90 | LPAR1 (0.34) | LPAR1LPAR3NAAAP2RX3 | |
| SCHEMBL19873553 | 0.90 | LPAR1 (0.34) | LPAR1LPAR3NAAAP2RX3 | |
| SCHEMBL19873663 | 0.87 | NAAA (0.41) | LPAR1LPAR3NAAASLC6A3ENPP2 | |
| SCHEMBL19873665 | 0.87 | NAAA (0.41) | LPAR1LPAR3NAAASLC6A3ENPP2 | |
| SCHEMBL19873603 | 0.87 | LPAR1 (0.49) | LPAR1LPAR3NAAA | |
| SCHEMBL19873602 | 0.87 | LPAR1 (0.49) | LPAR1LPAR3NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | claimed |
| EP-2940013-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND | UBE INDUSTRIES (JP) | 2018-02-21 | — | — | EP | claimed |