Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LPAR1 | Q92633 | 12/20 | 0.46 |
| ▸ | LPAR3 | Q9UBY5 | 6/20 | 0.46 |
| ▸ | DGAT1 | O75907 | 4/20 | 0.36 |
| ▸ | DHODH | Q02127 | 1/20 | 0.35 |
| ▸ | NAAA | Q02083 | 1/20 | 0.35 |
| ▸ | RORC | P51449 | 1/20 | 0.34 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.34 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.34 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.34 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | ABCB4 | P21439 | 1/20 | 0.34 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.34 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.34 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19873635 | 1.00 | LPAR1 (0.46) | LPAR1LPAR3DGAT1DHODHNAAA | |
| SCHEMBL19873602 | 0.89 | LPAR1 (0.49) | LPAR1LPAR3DGAT1NAAAABCC3 | |
| SCHEMBL19873603 | 0.89 | LPAR1 (0.49) | LPAR1LPAR3DGAT1NAAAABCC3 | |
| SCHEMBL19873652 | 0.89 | LPAR1 (0.36) | LPAR1LPAR3DGAT1NAAA | |
| SCHEMBL17215331 | 0.86 | LPAR1 (0.52) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL17215332 | 0.86 | LPAR1 (0.52) | LPAR1LPAR3ABCC3ABCC4ABCB11 | |
| SCHEMBL19873626 | 0.86 | DGAT1 (0.33) | LPAR1LPAR3DGAT1 | |
| SCHEMBL17367404 | 0.85 | LPAR1 (0.46) | LPAR1LPAR3RORCABCC3ABCC4 | |
| SCHEMBL19873623 | 0.83 | LPAR1 (0.44) | LPAR1LPAR3DHODHNAAA | |
| SCHEMBL19873620 | 0.83 | LPAR1 (0.44) | LPAR1LPAR3DHODHNAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3360869-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND USEFUL FOR THE TREATMENT OF DISEASES CAUSED BY LPA. | UBE INDUSTRIES (JP) | 2020-07-29 | — | — | EP | claimed |
| EP-2940013-B1 | HALOGEN-SUBSTITUTED HETEROCYCLIC COMPOUND | UBE INDUSTRIES (JP) | 2018-02-21 | — | — | EP | claimed |