Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 3/20 | 0.39 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | CNR2 | P34972 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | GCK | P35557 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17295745 | 0.87 | RAB9A (0.39) | RAB9ASMN1; SMN2ALDH1A1NPC1DGAT1 | |
| SCHEMBL19874404 | 0.84 | RAB9A (0.43) | RAB9ASMN1; SMN2ALDH1A1NPC1DGAT1 | |
| SCHEMBL19874327 | 0.84 | RAB9A (0.45) | RAB9ASMN1; SMN2ALDH1A1NPC1GCK | |
| SCHEMBL19874334 | 0.80 | RAB9A (0.35) | RAB9ASMN1; SMN2ALDH1A1NPC1POLB | |
| SCHEMBL17295691 | 0.76 | RAB9A (0.38) | RAB9ASMN1; SMN2ALDH1A1NPC1HTT | |
| SCHEMBL19874210 | 0.76 | RAB9A (0.34) | RAB9ASMN1; SMN2ALDH1A1NPC1POLB | |
| SCHEMBL19874138 | 0.75 | F11 (0.46) | — | |
| SCHEMBL19874340 | 0.74 | RAB9A (0.34) | RAB9ASMN1; SMN2ALDH1A1NPC1POLB | |
| SCHEMBL19874339 | 0.74 | RAB9A (0.34) | RAB9ASMN1; SMN2ALDH1A1NPC1POLB | |
| SCHEMBL17479470 | 0.74 | RAB9A (0.36) | RAB9ASMN1; SMN2ALDH1A1NPC1DGAT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3500556-B1 | PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS | MERCK SHARP & DOHME LLC (US) | 2023-08-02 | — | — | EP | disclosed |
| EP-3500556-A1 | PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2019-06-26 | — | — | EP | disclosed |
| US-10143681-B2 | Factor XIa inhibitors | MERCK SHARP & DOHME CORP. (US) | 2018-12-04 | — | — | US | disclosed |
| WO-2018039094-A1 | PYRIDINE-1-OXIDE DERIVATIVES AND THEIR USE AS FACTOR XIA INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2018-03-01 | — | — | WO | disclosed |
| US-20180050022-A1 | FACTOR XIa INHIBITORS | MERCK SHARP & DOHME CORP (US) | 2018-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10143681-B2 | Factor XIa inhibitors | F11, F2, TFPI | C5AR1 337/4885GPR119 4169/4885RAB9A 1808/4885 |
| US-20180050022-A1 | FACTOR XIa INHIBITORS | F11, F2, TFPI | C5AR1 337/4885GPR119 4169/4885RAB9A 1808/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.