Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | S100B | P04271 | 1/20 | 0.35 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.33 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19890354 | 0.83 | FYN (0.48) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL16290800 | 0.83 | ERN1 (0.36) | ABCB1ABCC1FYNSCN9A | |
| SCHEMBL16306439 | 0.79 | FYN (0.34) | ABCB1ABCC1FYNSCN9A | |
| SCHEMBL16290599 | 0.79 | KIT (0.35) | CYP3A4TSHRABCB1ABCC1FYN | |
| SCHEMBL569225 | 0.76 | L3MBTL1 (0.54) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL30313255 | 0.76 | L3MBTL1 (0.54) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL19886441 | 0.76 | CYP3A4 (0.39) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL6371301 | 0.74 | GAA (0.56) | ALDH1A1CYP3A4TSHRHSD17B10TDP1 | |
| SCHEMBL16303551 | 0.73 | FPR2 (0.36) | ABCB1ABCC1FYNSCN9A | |
| SCHEMBL16290729 | 0.73 | SCN9A (0.39) | SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-107531705-B | Bicyclic ketone sulfonamide compounds | 美国安进公司 | 2020-09-18 | — | — | CN | disclosed |
| US-10472356-B2 | Bicyclic ketone sulfonamide compounds | AMGEN INC. (US) | 2019-11-12 | — | — | US | disclosed |
| US-10472356-B2 | Bicyclic ketone sulfonamide compounds | AMGEN INC. (US) | 2019-11-12 | — | — | US | disclosed |
| EP-3265465-B1 | BICYCLIC KETONE SULFONAMIDE COMPOUNDS | AMGEN INC (US) | 2019-04-24 | — | — | EP | disclosed |
| EP-3265465-B1 | BICYCLIC KETONE SULFONAMIDE COMPOUNDS | AMGEN INC (US) | 2019-04-24 | — | — | EP | disclosed |
| US-20180051021-A1 | BICYCLIC KETONE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2018-02-22 | — | — | US | disclosed |
| US-20180051021-A1 | BICYCLIC KETONE SULFONAMIDE COMPOUNDS | AMGEN INC. (US) | 2018-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10472356-B2 | Bicyclic ketone sulfonamide compounds | TRPV1, TRPA1, KCNJ11 | ALDH1A1 601/4885CYP3A4 993/4885TSHR 3998/4885 |
| US-20180051021-A1 | BICYCLIC KETONE SULFONAMIDE COMPOUNDS | TRPV1, TRPA1, KCNJ11 | ALDH1A1 601/4885CYP3A4 993/4885TSHR 3998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.