Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.46 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 3/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.43 |
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.41 |
| ▸ | CKS1B | P61024 | 1/20 | 0.41 |
| ▸ | SKP1 | P63208 | 1/20 | 0.41 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.41 |
| ▸ | PCSK9 | Q8NBP7 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.38 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.38 |
| ▸ | STK17B | O94768 | 1/20 | 0.38 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19875166 | 0.89 | ADORA3 (0.48) | ADORA3ADORA2AIRAK4JAK2NTRK1 | |
| SCHEMBL15891391 | 0.84 | CA12 (0.45) | ADORA3ADORA2AIRAK4JAK2NTRK1 | |
| SCHEMBL18386990 | 0.83 | ADORA3 (0.49) | ADORA3ADORA2AIRAK4JAK2NTRK1 | |
| SCHEMBL19875183 | 0.81 | IRAK4 (0.76) | IRAK4 | |
| SCHEMBL19875194 | 0.81 | JAK2 (0.45) | ADORA3ADORA2AIRAK4JAK2NTRK1 | |
| SCHEMBL16936088 | 0.77 | NTRK1 (0.44) | ADORA3ADORA2AJAK2NTRK1SCN9A | |
| SCHEMBL15891392 | 0.77 | FYN (0.45) | JAK2NTRK1CA12CA1CA2 | |
| SCHEMBL16935995 | 0.75 | SCN9A (0.41) | ADORA3ADORA2AIRAK4JAK2NTRK1 | |
| SCHEMBL24858710 | 0.75 | MAPT (0.54) | ADORA3ADORA2ACA12CA1CA2 | |
| SCHEMBL14848202 | 0.74 | TDP1 (0.45) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3268367-B1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME (US) | 2022-10-05 | — | — | EP | disclosed |
| US-10155765-B2 | Carboxamide inhibitors of IRAK4 activity | MERCK SHARP & DOHME CORP. (US) | 2018-12-18 | — | — | US | disclosed |
| US-20180051027-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | MERCK SHARP & DOHME CORP. (US) | 2018-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180051027-A1 | CARBOXAMIDE INHIBITORS OF IRAK4 ACTIVITY | IRAK4, IRAK2, IRAK1 | ADORA3 2785/4885ADORA2A 2968/4885IRAK4 1/4885 |
| US-10155765-B2 | Carboxamide inhibitors of IRAK4 activity | IRAK4, IRAK2, IRAK1 | ADORA3 2785/4885ADORA2A 2968/4885IRAK4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.