Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | ABL1 | P00519 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | SRC | P12931 | 1/20 | 0.39 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.39 |
| ▸ | ITK | Q08881 | 3/20 | 0.39 |
| ▸ | EGFR | P00533 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 6/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 5/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 5/20 | 0.39 |
| ▸ | HDAC10 | Q969S8 | 5/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15891393 | 0.85 | RET (0.44) | RETFYNGFERHDAC1HDAC6 | |
| SCHEMBL15891392 | 0.84 | FYN (0.45) | CA1CA2RETFYNITK | |
| SCHEMBL16084626 | 0.79 | L3MBTL1 (0.41) | RETFYN | |
| SCHEMBL15891391 | 0.75 | CA12 (0.45) | TDP1CA1CA2 | |
| SCHEMBL16975591 | 0.74 | CSNK2A1 (0.49) | CA1CA2FYNITKEGFR | |
| SCHEMBL19875239 | 0.74 | ADORA3 (0.46) | CA1CA2 | |
| SCHEMBL15894592 | 0.73 | CSNK2A1 (0.43) | FYNITKEGFRSUCNR1 | |
| SCHEMBL15891373 | 0.71 | CSNK2A1 (0.52) | RETFYN | |
| SCHEMBL16084590 | 0.71 | FLT3 (0.34) | CA1CA2 | |
| SCHEMBL15891381 | 0.71 | CSNK2A1 (0.50) | CA1CA2FYNITKEGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9370520-B2 | Macrocyclic LRRK2 kinase inhibitors | IPSEN PHARMA S.A.S. (FR) | 2016-06-21 | — | — | US | disclosed |
| US-9370520-B2 | Macrocyclic LRRK2 kinase inhibitors | IPSEN PHARMA S.A.S. (FR) | 2016-06-21 | — | — | US | disclosed |
| US-20150290198-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2015-10-15 | — | — | US | disclosed |
| US-20150290198-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2015-10-15 | — | — | US | disclosed |
| US-9096609-B2 | Macrocyclic LRRK2 kinase inhibitors | IPSEN PHARMA S.A.S. (FR) | 2015-08-04 | — | — | US | disclosed |
| US-9096609-B2 | Macrocyclic LRRK2 kinase inhibitors | IPSEN PHARMA S.A.S. (FR) | 2015-08-04 | — | — | US | disclosed |
| US-20140206683-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2014-07-24 | — | — | US | disclosed |
| US-20140206683-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | ONCODESIGN S.A. (FR) | 2014-07-24 | — | — | US | disclosed |
| WO-2013046029-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | IPSEN PHARMA S.A.S. (FR) | 2013-04-04 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150290198-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LRRK2, PINK1, PARK7 | TDP1 981/4885CA1 4687/4885CA2 4634/4885 |
| US-20140206683-A1 | MACROCYCLIC LRRK2 KINASE INHIBITORS | LRRK2, PINK1, PARK7 | TDP1 981/4885CA1 4687/4885CA2 4634/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.