Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.64 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.64 |
| ▸ | TAS1R2 | Q8TE23 | 2/20 | 0.64 |
| ▸ | NPC1 | O15118 | 2/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | GLA | P06280 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.51 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | DRD4 | P21917 | 1/20 | 0.48 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14688259 | 0.94 | TAS1R3 (0.62) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL22123764 | 0.89 | TAS1R3 (0.57) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL20477095 | 0.89 | SMN1; SMN2 (0.57) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL20477092 | 0.88 | TAS1R3 (0.56) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL457993 | 0.86 | NPC1 (0.84) | NPC1RAB9AP2RX7SMN1; SMN2GLA | |
| SCHEMBL29062256 | 0.84 | TAS1R3 (0.54) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL28785590 | 0.84 | TAS1R3 (0.54) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL695642 | 0.83 | P2RX7 (0.71) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL19155146 | 0.83 | NPC1 (0.60) | TAS1R3TAS1R1TAS1R2NPC1RAB9A | |
| SCHEMBL3172457 | 0.83 | TAS1R3 (0.59) | TAS1R3TAS1R1TAS1R2NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1501830-B1 | 7-ARYL-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE DERIVATIVES AND THEIR USE AS RENIN INHIBITORS IN THE TREATMENT OF HYPERTENSION, CARDIOVASCULAR OR RENAL DISEASES | ACTELION PHARMACEUTICALS LTD (CH) | 2011-10-05 | — | — | EP | claimed |
| EP-1846407-B1 | 7-{4-[2-(2,6-DICHLORO-4-METHYLPHENOXY)ETHOXY]PHENYL}-3,9-DIAZABICYCLO[3.3.1]NON-6-ENE-6-CARBOXYLIC ACID CYCLOPROPYL-(2,3-DIMETHYLBENZYL)AMIDE AS INHIBITOR OF RENIN FOR THE TREATMENT OF HYPERTENSION. | ACTELION PHARMACEUTICALS LTD (CH) | 2011-06-29 | — | — | EP | claimed |
| EP-1786814-B1 | BICYCLONONENE DERIVATIVES AS RENIN INHIBITORS | ACTELION PHARMACEUTICALS LTD (CH) | 2010-03-31 | — | — | EP | claimed |
| EP-1620403-B1 | NOVEL 3,4-DISUBSTITUTED 1,2,3,6-TETRAHYDROPYRIDINE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-11-28 | — | — | EP | claimed |
| WO-2007049224-A1 | NOVEL HEXAHYDRO- OR OCTAHYDRO-CYCLOPENTA[C]PYRROLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-05-03 | — | — | WO | claimed |
| WO-2013084241-A1 | COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2013-06-13 | — | — | WO | disclosed |
| WO-2012085935-A2 | COMPOUNDS AS INHIBITORS OF RENIN | CADILA HEALTHCARE LIMITED (IN) | 2012-06-28 | — | — | WO | disclosed |
| WO-2007049224-A1 | NOVEL HEXAHYDRO- OR OCTAHYDRO-CYCLOPENTA[C]PYRROLE DERIVATIVES | ACTELION PHARMACEUTICALS LTD (CH) | 2007-05-03 | — | — | WO | disclosed |