Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 2/20 | 0.68 |
| ▸ | F12 | P00748 | 1/20 | 0.68 |
| ▸ | NCF1 | P14598 | 1/20 | 0.68 |
| ▸ | NOS3 | P29474 | 1/20 | 0.68 |
| ▸ | NOS1 | P29475 | 1/20 | 0.68 |
| ▸ | NOS2 | P35228 | 1/20 | 0.68 |
| ▸ | BACE1 | P56817 | 1/20 | 0.68 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.52 |
| ▸ | PARP1 | P09874 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.52 |
| ▸ | RECQL | P46063 | 1/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29377365 | 0.82 | PLAU (1.00) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL49220 | 0.82 | PLAU (1.00) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL28116864 | 0.80 | PLAU (0.95) | PLAUF12NCF1NOS3NOS1 | |
| Iodide SCHEMBL29988059 | 0.80 | PLAU (0.95) | PLAUF12NCF1NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL509104 | 0.80 | PLAU (0.95) | PLAUF12NCF1NOS3NOS1 | |
| Formic Acid SCHEMBL30738145 | 0.80 | F12 (0.78) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL7570484 | 0.78 | CNR2 (0.48) | PLAUF12NCF1NOS3NOS1 | |
| Methylglyoxal SCHEMBL6002250 | 0.77 | F12 (0.68) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL5735418 | 0.77 | CSNK2A1 (0.61) | PLAUF12NCF1NOS3NOS1 | |
| SCHEMBL6436253 | 0.77 | CSNK2A1 (0.54) | PLAUF12NCF1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4011882-A1 | 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES | Purdue Research Foundation (US) | 2022-06-15 | — | — | EP | disclosed |
| US-20210198208-A1 | 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES | PURDUE RESEARCH FOUNDATION (US) | 2021-07-01 | — | — | US | disclosed |
| US-11001559-B2 | 4-substituted aminoisoquinoline derivatives | PURDUE RESEARCH FOUNDATION (US) | 2021-05-11 | — | — | US | disclosed |
| EP-3496717-A1 | 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES | Purdue Research Foundation (US) | 2019-06-19 | — | — | EP | disclosed |
| US-20190177278-A1 | 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES | PURDUE RESEARCH FOUNDATION (US) | 2019-06-13 | — | — | US | disclosed |
| CN-109843294-A | The aminoisoquinoline derivatives that 4- replaces | 普渡研究基金会 | 2019-06-04 | — | — | CN | disclosed |
| WO-2018035072-A1 | 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES | PURDUE RESEARCH FOUNDATION (US) | 2018-02-22 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190177278-A1 | 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES | MCL1, ABL1, FLT3 | PLAU 4446/4885F12 4777/4885NCF1 952/4885 |
| US-11001559-B2 | 4-substituted aminoisoquinoline derivatives | MCL1, ABL1, FLT3 | PLAU 4446/4885F12 4777/4885NCF1 952/4885 |
| US-20210198208-A1 | 4-SUBSTITUTED AMINOISOQUINOLINE DERIVATIVES | MCL1, ABL1, FLT3 | PLAU 4446/4885F12 4777/4885NCF1 952/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.