Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 3/20 | 0.78 |
| ▸ | PLAU | P00749 | 2/20 | 0.78 |
| ▸ | NCF1 | P14598 | 1/20 | 0.78 |
| ▸ | NOS3 | P29474 | 1/20 | 0.78 |
| ▸ | NOS1 | P29475 | 1/20 | 0.78 |
| ▸ | NOS2 | P35228 | 1/20 | 0.78 |
| ▸ | BACE1 | P56817 | 1/20 | 0.78 |
| ▸ | ROCK1 | Q13464 | 7/20 | 0.48 |
| ▸ | PLG | P00747 | 2/20 | 0.46 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | F11 | P03951 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL49220 | 0.88 | PLAU (1.00) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL29377365 | 0.88 | PLAU (1.00) | F12PLAUNCF1NOS3NOS1 | |
| Methylglyoxal SCHEMBL6002250 | 0.86 | F12 (0.68) | F12PLAUNCF1NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL509104 | 0.86 | PLAU (0.95) | F12PLAUNCF1NOS3NOS1 | |
| Iodide SCHEMBL29988059 | 0.86 | PLAU (0.95) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL28116864 | 0.86 | PLAU (0.95) | F12PLAUNCF1NOS3NOS1 | |
| Benzamide SCHEMBL19877173 | 0.80 | PLAU (0.68) | F12PLAUNCF1NOS3NOS1 | |
| Formic Acid SCHEMBL28681087 | 0.78 | CYP2A6 (0.78) | F12PLAUNCF1NOS3NOS1 | |
| Quinoline SCHEMBL28251904 | 0.76 | NCF1 (0.75) | F12PLAUNCF1NOS3NOS1 | |
| Formic Acid SCHEMBL30493146 | 0.73 | KDM4E (0.47) | F12PLAUNCF1NOS3NOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4536356-A1 | PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | Xenon Pharmaceuticals Inc. (CA) | 2025-04-16 | — | — | EP | disclosed |
| WO-2023239729-A1 | PYRIDINAMINE DERIVATIVES AND THEIR USE AS POTASSIUM CHANNEL MODULATORS | XENON PHARMACEUTICALS INC. (CA) | 2023-12-14 | — | — | WO | disclosed |