Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F12 | P00748 | 3/20 | 0.68 |
| ▸ | PLAU | P00749 | 2/20 | 0.68 |
| ▸ | NCF1 | P14598 | 1/20 | 0.68 |
| ▸ | NOS3 | P29474 | 1/20 | 0.68 |
| ▸ | NOS1 | P29475 | 1/20 | 0.68 |
| ▸ | NOS2 | P35228 | 1/20 | 0.68 |
| ▸ | BACE1 | P56817 | 1/20 | 0.68 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 4/20 | 0.43 |
| ▸ | PLG | P00747 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 4/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | F7 | P08709 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Formic Acid SCHEMBL30738145 | 0.86 | F12 (0.78) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL49220 | 0.82 | PLAU (1.00) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL29377365 | 0.82 | PLAU (1.00) | F12PLAUNCF1NOS3NOS1 | |
| Iodide SCHEMBL29988059 | 0.80 | PLAU (0.95) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL28116864 | 0.80 | PLAU (0.95) | F12PLAUNCF1NOS3NOS1 | |
| Hydrochloric Acid SCHEMBL509104 | 0.80 | PLAU (0.95) | F12PLAUNCF1NOS3NOS1 | |
| Benzamide SCHEMBL19877173 | 0.77 | PLAU (0.68) | F12PLAUNCF1NOS3NOS1 | |
| SCHEMBL27593728 | 0.71 | CNR2 (0.50) | F12PLAUNCF1NOS3NOS1 | |
| Quinoline SCHEMBL28251904 | 0.71 | NCF1 (0.75) | F12PLAUNCF1NOS3NOS1 | |
| Methylglyoxal SCHEMBL6013420 | 0.71 | NOS3 (0.68) | PLAUNOS3NOS1NOS2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20060258612-A1 | CFTR channel modulators | CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (FR) | 2006-11-16 | — | — | US | disclosed |
| EP-1678175-A2 | CFTR CHANNEL MODULATORS | Universite Joseph Fourier (FR) | 2006-07-12 | — | — | EP | disclosed |
| WO-2005039589-A2 | CFTR CHANNEL MODULATORS | UNIVERSITE JOSEPH FOURIER (FR) | 2005-05-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060258612-A1 | CFTR channel modulators | CFTR, SCNN1B, SCNN1A | F12 937/4885PLAU 4539/4885NCF1 3224/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.