Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC1A3 | P43003 | 2/20 | 0.47 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.47 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.42 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9725057 | 0.84 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL4412609 | 0.84 | SLC1A3 (0.41) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL4409728 | 0.82 | SLC1A3 (0.40) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL4411610 | 0.82 | SLC1A3 (0.40) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL27865431 | 0.81 | TDP1 (0.41) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL23279577 | 0.79 | TRPA1 (0.44) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL7159471 | 0.79 | SLC1A3 (0.43) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL14021052 | 0.79 | SLC1A3 (0.43) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL10439884 | 0.78 | SLC1A2 (0.59) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 | |
| SCHEMBL5269098 | 0.78 | SLC1A2 (0.59) | SLC1A3SLC1A2SLC1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20130195954-A1 | FILMS AND PARTICLES | THE TRUSTEES OF THE BOSTON UNIVERSITY (US) | 2013-08-01 | — | — | US | disclosed |
| US-8338492-B2 | Films and particles | THE TRUSTEES OF THE BOSTON UNIVERSITY (US) | 2012-12-25 | — | — | US | disclosed |
| US-8334324-B2 | Films and particles | THE TRUSTEES OF THE BOSTON UNIVERSITY (US) | 2012-12-18 | — | — | US | disclosed |
| US-20120107365-A1 | FILMS AND PARTICLES | THE TRUSTEES OF THE BOSTON UNIVERSITY (US) | 2012-05-03 | — | — | US | disclosed |
| US-20110152305-A1 | FILMS AND PARTICLES | THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) | 2011-06-23 | — | — | US | disclosed |
| US-7671095-B2 | Films and particles | THE TRUSTEES OF THE BOSTON UNIVERSITY (US) | 2010-03-02 | — | — | US | disclosed |
| EP-2032623-A2 | FILMS AND PARTICLES | The Trustees of the Boston University (US) | 2009-03-11 | — | — | EP | disclosed |
| US-20080075718-A1 | Films and Particles | THE TRUSTEES OF THE BOSTON UNIVERSITY | 2008-03-27 | — | — | US | disclosed |
| WO-2007140483-A2 | FILMS AND PARTICLES | THE TRUSTEES OF THE BOSTON UNIVERSITY (US) | 2007-12-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152305-A1 | FILMS AND PARTICLES | APOB, PGF, ACTB | SLC1A3 4811/4885SLC1A2 4867/4885SLC1A1 4813/4885 |
| US-20130195954-A1 | FILMS AND PARTICLES | APOB, PGF, ACTB | SLC1A3 4811/4885SLC1A2 4867/4885SLC1A1 4813/4885 |
| US-20080075718-A1 | Films and Particles | APOB, PGF, ACTB | SLC1A3 4811/4885SLC1A2 4867/4885SLC1A1 4813/4885 |
| US-20120107365-A1 | FILMS AND PARTICLES | APOB, PGF, ACTB | SLC1A3 4811/4885SLC1A2 4867/4885SLC1A1 4813/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.