Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TPH1 | P17752 | 17/20 | 0.61 |
| ▸ | TPH2 | Q8IWU9 | 17/20 | 0.61 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | PKM | P14618 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19891088 | 0.89 | TPH2 (0.61) | TPH1TPH2GRIN1GRIN2B | |
| SCHEMBL19891057 | 0.87 | TPH2 (0.64) | TPH1TPH2 | |
| SCHEMBL19891024 | 0.82 | TPH2 (0.56) | TPH1TPH2 | |
| SCHEMBL19891014 | 0.77 | TPH1 (0.56) | TPH1TPH2GAA | |
| SCHEMBL18036500 | 0.76 | TPH2 (1.00) | TPH1TPH2 | |
| SCHEMBL19891015 | 0.71 | TPH1 (0.57) | TPH1TPH2 | |
| SCHEMBL19874755 | 0.68 | TPH2 (1.00) | TPH1TPH2 | |
| SCHEMBL18036493 | 0.66 | TPH2 (0.84) | TPH1TPH2 | |
| SCHEMBL18036509 | 0.66 | TPH2 (1.00) | TPH1TPH2 | |
| SCHEMBL18036511 | 0.66 | TPH2 (1.00) | TPH1TPH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180051025-A1 | XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME | Max-Delbrück-Centrum für Molekulare Medizin (DE) | 2018-02-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180051025-A1 | XANTHINE DERIVATIVES, THEIR USE AS A MEDICAMENT, AND PHARMACEUTICAL PREPARATIONS COMPRISING THE SAME | TPH1, XDH, TPH2 | TPH1 1/4885TPH2 3/4885GAA 1254/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.