Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 6/20 | 0.53 |
| ▸ | FER | P16591 | 2/20 | 0.44 |
| ▸ | BTK | Q06187 | 2/20 | 0.39 |
| ▸ | TYK2 | P29597 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 8/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1984696 | 0.88 | SYK (0.69) | SYKFERBTKTYK2JAK2 | |
| SCHEMBL1990177 | 0.88 | SYK (0.59) | SYKFERBTKTYK2JAK2 | |
| SCHEMBL1990162 | 0.88 | SYK (0.59) | SYKFERBTKTYK2JAK2 | |
| SCHEMBL29949698 | 0.84 | SYK (0.53) | SYKFERBTKTYK2 | |
| SCHEMBL22475426 | 0.84 | SYK (0.53) | SYKFERBTKTYK2 | |
| SCHEMBL14930598 | 0.84 | SYK (0.53) | SYKFERBTKTYK2 | |
| SCHEMBL16751349 | 0.83 | SYK (0.56) | SYKFERBTKTYK2 | |
| SCHEMBL21031602 | 0.83 | SYK (0.75) | SYKFERBTKTYK2JAK2 | |
| SCHEMBL1993418 | 0.83 | SYK (0.75) | SYKFERBTKTYK2JAK2 | |
| SCHEMBL22475355 | 0.83 | SYK (0.75) | SYKFERBTKTYK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110152273-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-06-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110152273-A1 | FUSED HETEROAROMATIC PYRROLIDINONES | SYK, ZAP70, LYN | SYK 1/4885FER 62/4885BTK 6/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.