Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | FKBP1A | P62942 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 2/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | CPB1 | P15086 | 1/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19910781 | 1.00 | HTR2C (0.47) | HTR2CALDH1A1FKBP1ATSHRCYP3A4 | |
| SCHEMBL19898539 | 1.00 | HTR2C (0.47) | HTR2CALDH1A1FKBP1ATSHRCYP3A4 | |
| SCHEMBL6627266 | 0.85 | PREP (0.48) | HTR2CALDH1A1FKBP1ATSHRCYP3A4 | |
| SCHEMBL19898838 | 0.84 | HTR2C (0.48) | HTR2CALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL19910780 | 0.84 | HTR2C (0.48) | HTR2CALDH1A1TSHRMEN1KMT2A | |
| SCHEMBL6625440 | 0.84 | FKBP1A (0.47) | HTR2CALDH1A1FKBP1ATSHRCYP3A4 | |
| SCHEMBL15436131 | 0.83 | FKBP1A (0.45) | HTR2CFKBP1ATSHRMEN1KMT2A | |
| SCHEMBL6625918 | 0.83 | FKBP1A (0.52) | HTR2CALDH1A1FKBP1ATSHRCYP3A4 | |
| SCHEMBL6625451 | 0.83 | FKBP1A (0.46) | HTR2CALDH1A1FKBP1ATSHRCYP3A4 | |
| SCHEMBL6628463 | 0.82 | FKBP1A (0.51) | HTR2CALDH1A1FKBP1ATSHRCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11020398-B2 | Amino-pyrrolopyrimidinone compounds and methods of use thereof | ARQULE, INC. (US) | 2021-06-01 | — | — | US | disclosed |
| US-20180055846-A1 | AMINO-PYRROLOPYRIMIDINONE COMPOUNDS AND METHODS OF USE THEREOF | ARQULE, INC. | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11020398-B2 | Amino-pyrrolopyrimidinone compounds and methods of use thereof | BTK, SYK, LCK | HTR2C 2931/4885ALDH1A1 3677/4885FKBP1A 377/4885 |
| US-20180055846-A1 | AMINO-PYRROLOPYRIMIDINONE COMPOUNDS AND METHODS OF USE THEREOF | BTK, SYK, LCK | HTR2C 2931/4885ALDH1A1 3677/4885FKBP1A 377/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.