Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FKBP1A | P62942 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | ELANE | P08246 | 7/20 | 0.44 |
| ▸ | F2 | P00734 | 3/20 | 0.44 |
| ▸ | CTSG | P08311 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | PREP | P48147 | 1/20 | 0.43 |
| ▸ | MITF | O75030 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | PRCP | P42785 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6625440 | 0.90 | FKBP1A (0.47) | FKBP1AHTR2CNPSR1PREPMITF | |
| SCHEMBL6625918 | 0.83 | FKBP1A (0.52) | FKBP1AHTR2CNPSR1PREPMITF | |
| SCHEMBL19898733 | 0.83 | HTR2C (0.47) | FKBP1AHTR2CNPSR1PREPMITF | |
| SCHEMBL6627266 | 0.83 | PREP (0.48) | FKBP1AHTR2CNPSR1PREPMITF | |
| SCHEMBL19910781 | 0.83 | HTR2C (0.47) | FKBP1AHTR2CNPSR1PREPMITF | |
| SCHEMBL19898539 | 0.83 | HTR2C (0.47) | FKBP1AHTR2CNPSR1PREPMITF | |
| SCHEMBL12034010 | 0.82 | HTR2C (0.44) | FKBP1AHTR2CELANEF2CTSG | |
| SCHEMBL12034260 | 0.82 | HTR2C (0.44) | FKBP1AHTR2CELANEF2CTSG | |
| SCHEMBL6628463 | 0.82 | FKBP1A (0.51) | FKBP1AHTR2CNPSR1PREPMITF | |
| SCHEMBL9546447 | 0.81 | HTR2C (0.57) | FKBP1AHTR2CNPSR1PREPMITF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1098897-B1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION | AGOURON PHARMA (US) | 2004-06-09 | — | — | EP | disclosed |
| US-6630472-B1 | Peptidyl-prolyl isomerase inhibitors | PFIZER INC | 2003-10-07 | — | — | US | disclosed |
| EP-1098897-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION | AGOURON PHARMACEUTICALS, INC. (US) | 2001-05-16 | — | — | EP | disclosed |
| WO-2000004020-A1 | COMPOUNDS, COMPOSITIONS, AND METHODS FOR STIMULATING NEURONAL GROWTH AND ELONGATION | AGOURON PHARMACEUTICALS, INC. (US) | 2000-01-27 | — | — | WO | disclosed |