Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.51 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | PYGL | P06737 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | PIN1 | Q13526 | 1/20 | 0.42 |
| ▸ | PLD2 | O14939 | 1/20 | 0.41 |
| ▸ | PLD1 | Q13393 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14845703 | 0.84 | PIN1 (0.62) | HRH4HDAC2KDM4EGAAALDH1A1 | |
| SCHEMBL12501351 | 0.83 | ALOX15 (0.55) | HRH4CYP2A6KEAP1HDAC2KDM4E | |
| SCHEMBL25782820 | 0.82 | F7 (0.60) | HRH4KMT2APYGLNPC1RAB9A | |
| SCHEMBL13334344 | 0.82 | TP53 (0.47) | HRH4KDM4EGAAKMT2AALDH1A1 | |
| SCHEMBL12669766 | 0.80 | KDM4E (0.64) | KDM4EGAAALDH1A1MAPK1NPC1 | |
| SCHEMBL12392310 | 0.80 | HRH4 (0.55) | HRH4CYP2A6KEAP1KDM4EALDH1A1 | |
| SCHEMBL12826973 | 0.80 | KDM4E (0.64) | KDM4EGAAKMT2AALDH1A1PYGL | |
| SCHEMBL12848263 | 0.79 | ALOX15 (0.58) | HRH4CYP2A6KEAP1HDAC2KDM4E | |
| SCHEMBL12862877 | 0.78 | HRH4 (0.58) | HRH4CYP2A6KEAP1HDAC2KDM4E | |
| SCHEMBL1415238 | 0.77 | KDM4E (0.61) | HRH4HDAC2KDM4EALDH1A1PYGL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9901567-B2 | Substituted CC-1065 analogs and their conjugates | SYNTARGA B.V. (NL) | 2018-02-27 | — | — | US | disclosed |