Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 2/20 | 0.58 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.53 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.51 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
| ▸ | DRD3 | P35462 | 1/20 | 0.50 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | PYGL | P06737 | 1/20 | 0.47 |
| ▸ | SRC | P12931 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | NHERF1 | O14745 | 1/20 | 0.46 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1415238 | 0.89 | KDM4E (0.61) | ALOX15HDAC2KDM4EHRH4ALDH1A1 | |
| SCHEMBL13753366 | 0.84 | RAB9A (0.62) | ALOX15HDAC2KDM4EHRH4ALDH1A1 | |
| SCHEMBL13753882 | 0.84 | SRC (0.65) | ALOX15KDM4EHRH4ALDH1A1MAPT | |
| SCHEMBL12501351 | 0.83 | ALOX15 (0.55) | ALOX15HDAC2KDM4EHRH4ALDH1A1 | |
| SCHEMBL13753364 | 0.82 | CNR1 (0.62) | ALOX15HDAC2KDM4EHRH4ALDH1A1 | |
| SCHEMBL13753365 | 0.82 | ALOX15 (0.79) | ALOX15HRH4HRH3PYGLNHERF1 | |
| SCHEMBL15224031 | 0.80 | HRH4 (0.55) | HDAC2KDM4EHRH4ALDH1A1HRH3 | |
| SCHEMBL9397179 | 0.80 | DRD2 (0.74) | ALOX15HDAC2KDM4EALDH1A1DRD2 | |
| SCHEMBL13753883 | 0.80 | KDM4E (0.77) | HDAC2KDM4EALDH1A1MAPT | |
| SCHEMBL19901352 | 0.79 | HRH4 (0.51) | HDAC2KDM4EHRH4ALDH1A1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110065767-A1 | Substituted CC-1065 Analogs and Their Conjugates | SYNTARGA B.V. (NL) | 2011-03-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110065767-A1 | Substituted CC-1065 Analogs and Their Conjugates | PCNA, TOP1, TOP2B | ALOX15 2925/4885HDAC2 3002/4885KDM4E 752/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.