Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGLN1 | Q9GZT9 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.34 |
| ▸ | RECQL | P46063 | 2/20 | 0.34 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.34 |
| ▸ | FAAH | O00519 | 5/20 | 0.34 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | APEX1 | P27695 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | USP2 | O75604 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | BLM | P54132 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | GPR18 | Q14330 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1758271 | 0.83 | EGLN1 (0.38) | EGLN1ALDH1A1LMNAMAPTTDP1 | |
| SCHEMBL17029457 | 0.81 | MAOA (0.39) | RECQLGAA | |
| SCHEMBL22178703 | 0.77 | EGLN1 (0.39) | EGLN1ALDH1A1LMNAMAPTTDP1 | |
| SCHEMBL999017 | 0.77 | MEN1 (0.46) | EGLN1ALDH1A1LMNATDP1MEN1 | |
| SCHEMBL8500219 | 0.77 | MEN1 (0.46) | EGLN1ALDH1A1LMNATDP1MEN1 | |
| SCHEMBL1000860 | 0.77 | MEN1 (0.46) | EGLN1ALDH1A1LMNATDP1MEN1 | |
| SCHEMBL1486144 | 0.77 | MEN1 (0.46) | EGLN1ALDH1A1LMNATDP1MEN1 | |
| Water SCHEMBL6670447 | 0.76 | MEN1 (0.45) | EGLN1ALDH1A1LMNATDP1MEN1 | |
| SCHEMBL10277058 | 0.76 | EGLN1 (0.38) | EGLN1ALDH1A1LMNAMAPTTDP1 | |
| SCHEMBL13140609 | 0.75 | LMNA (0.38) | ALDH1A1LMNAMAPTRECQL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2961435-B1 | CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS | IMMUNOGEN INC (US) | 2019-05-01 | — | — | EP | disclosed |
| US-9901647-B2 | Conjugates comprising cell-binding agents and cytotoxic agents | IMMUNOGEN, INC. (US) | 2018-02-27 | — | — | US | disclosed |