Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 19/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 17/20 | 0.61 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902380 | 0.91 | ROCK2 (0.62) | ROCK2ROCK1 | |
| SCHEMBL17452927 | 0.89 | ROCK2 (0.55) | ROCK2ROCK1 | |
| SCHEMBL19902634 | 0.88 | ROCK2 (0.49) | ROCK2ROCK1 | |
| SCHEMBL19902640 | 0.87 | ROCK2 (0.48) | ROCK2ROCK1 | |
| SCHEMBL20229915 | 0.86 | ROCK2 (0.51) | ROCK2ROCK1MAPK14 | |
| SCHEMBL17452972 | 0.80 | ROCK2 (0.53) | ROCK2ROCK1 | |
| SCHEMBL19902719 | 0.79 | ROCK2 (0.52) | ROCK2ROCK1 | |
| SCHEMBL19902407 | 0.78 | ROCK2 (0.51) | ROCK2ROCK1 | |
| SCHEMBL19902646 | 0.78 | USP30 (0.55) | ROCK2ROCK1 | |
| SCHEMBL19902369 | 0.78 | ROCK2 (0.46) | ROCK2ROCK1MAPK14 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2018-06-07 | — | — | US | disclosed |
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | ROCK1, MYLK, ROCK2 | ROCK2 3/4885ROCK1 1/4885MAPK14 189/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.