Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | GOT1 | P17174 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MPO | P05164 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | THPO | P40225 | 1/20 | 0.40 |
| ▸ | AOX1 | Q06278 | 1/20 | 0.40 |
| ▸ | ACOX1 | Q15067 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17452596 | 0.86 | ROCK2 (0.48) | KDM4ETP53CYP3A4GOT1SMN1; SMN2 | |
| SCHEMBL1789261 | 0.78 | ATM (0.50) | KDM4EALDH1A1NPC1RAB9ALMNA | |
| SCHEMBL29586498 | 0.76 | LMNA (0.50) | KDM4ETP53CYP3A4GOT1SMN1; SMN2 | |
| SCHEMBL19902393 | 0.76 | ROCK2 (0.41) | KDM4ECYP3A4SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL4582703 | 0.74 | CYP1A2 (0.51) | KDM4ETP53CYP3A4GOT1SMN1; SMN2 | |
| SCHEMBL19902452 | 0.72 | SMN1; SMN2 (0.45) | CYP3A4SMN1; SMN2ALDH1A1NPC1RAB9A | |
| SCHEMBL19902376 | 0.72 | ROCK1 (0.53) | NPC1RAB9AROCK2PARP1ACP1 | |
| SCHEMBL1786583 | 0.72 | ATM (0.47) | KDM4ECYP3A4SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL1786994 | 0.72 | PRMT5 (0.48) | KDM4ECYP3A4SMN1; SMN2ALDH1A1NPC1 | |
| SCHEMBL19902689 | 0.72 | ROCK2 (0.46) | KDM4ECYP3A4SMN1; SMN2ALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2018-06-07 | — | — | US | disclosed |
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | ROCK1, MYLK, ROCK2 | KDM4E 1546/4885TP53 3738/4885CYP3A4 1654/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.