Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 3/20 | 0.40 |
| ▸ | PARP1 | P09874 | 9/20 | 0.38 |
| ▸ | PARP2 | Q9UGN5 | 2/20 | 0.36 |
| ▸ | ROCK1 | Q13464 | 3/20 | 0.36 |
| ▸ | TYK2 | P29597 | 2/20 | 0.35 |
| ▸ | TNKS | O95271 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | PARP6 | Q2NL67 | 1/20 | 0.35 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.35 |
| ▸ | PARP14 | Q460N5 | 1/20 | 0.35 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.35 |
| ▸ | TIPARP | Q7Z3E1 | 1/20 | 0.35 |
| ▸ | PARP8 | Q8N3A8 | 1/20 | 0.35 |
| ▸ | PARP16 | Q8N5Y8 | 1/20 | 0.35 |
| ▸ | PARP12 | Q9H0J9 | 1/20 | 0.35 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.35 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.35 |
| ▸ | PARP4 | Q9UKK3 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19902396 | 0.92 | ROCK2 (0.43) | ROCK2PARP1ROCK1TYK2PDE4B | |
| SCHEMBL19902643 | 0.90 | ROCK2 (0.38) | ROCK2PARP1PARP2ROCK1TNKS | |
| SCHEMBL17452922 | 0.89 | ROCK2 (0.53) | ROCK2PARP1ROCK1PRMT5WDR77 | |
| SCHEMBL19902519 | 0.86 | TGFBR1 (0.46) | ROCK2ROCK1PRMT5WDR77TGFBR1 | |
| SCHEMBL19902518 | 0.83 | CSF1R (0.46) | ROCK2PARP1ROCK1PRMT5WDR77 | |
| SCHEMBL19902451 | 0.83 | ROCK1 (0.44) | ROCK2PARP1ROCK1TGFBR1 | |
| SCHEMBL17452939 | 0.81 | ROCK2 (0.56) | ROCK2PARP1ROCK1 | |
| SCHEMBL19902489 | 0.81 | ROCK2 (0.40) | ROCK2ROCK1TYK2NPC1RAB9A | |
| SCHEMBL19902384 | 0.81 | ROCK2 (0.41) | ROCK2ROCK1TYK2NPC1RAB9A | |
| SCHEMBL19902345 | 0.80 | ROCK1 (0.53) | ROCK2ROCK1PRMT5WDR77TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | BRISTOL MYERS SQUIBB CO (US) | 2018-06-07 | — | — | US | disclosed |
| US-9902702-B2 | Spirocycloheptanes as inhibitors of rock | BRISTOL-MYERS SQUIBB COMPANY (US) | 2018-02-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180155296-A1 | SPIROCYCLOHEPTANES AS INHIBITORS OF ROCK | ROCK1, MYLK, ROCK2 | ROCK2 3/4885PARP1 1915/4885PARP2 2621/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.