Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1D | P28221 | 1/20 | 0.59 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.50 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.47 |
| ▸ | ESR1 | P03372 | 1/20 | 0.46 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 1/20 | 0.43 |
| ▸ | HSD17B2 | P37059 | 1/20 | 0.43 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.41 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.41 |
| ▸ | GSTP1 | P09211 | 1/20 | 0.41 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.41 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17179248 | 0.89 | HSD11B1 (0.58) | HTR1DHSD11B1CYP2A6ESR1ESR2 | |
| SCHEMBL18029140 | 0.87 | HSD11B1 (0.55) | HTR1DHSD11B1CYP2A6ESR1ESR2 | |
| SCHEMBL21237213 | 0.79 | FAAH (0.46) | CYP2A6ESR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL14363730 | 0.78 | HSD11B1 (0.48) | HTR1DHSD11B1CYP2A6NPC1FAAH | |
| SCHEMBL18029231 | 0.76 | HTR6 (0.60) | HTR1DHSD11B1CYP2A6MAPTHTR6 | |
| SCHEMBL15028093 | 0.76 | PRKCI (0.48) | HSD11B1CYP2A6KDM4EALDH1A1MAPT | |
| SCHEMBL5256926 | 0.76 | HSD11B1 (0.69) | HSD11B1CYP2A6HTR6FAAH | |
| SCHEMBL30241674 | 0.76 | HSD11B1 (0.69) | HSD11B1CYP2A6HTR6FAAH | |
| SCHEMBL5350949 | 0.75 | ESR1 (0.67) | HTR1DESR1ESR2KDM4ENPC1 | |
| SCHEMBL29812 | 0.75 | CDK4 (0.56) | HSD11B1CYP2A6KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3911658-B1 | METHOD FOR PREPARATION OF FLUORO ALKYLATED COMPOUNDS BY HOMOGENEOUS NI CATALYSIS | ARXADA AG (CH) | 2023-01-11 | — | — | EP | disclosed |
| US-11530175-B2 | Method for preparation of fluoro alkylated compounds by homogeneous Ni catalysis | ARXADA AG (CH) | 2022-12-20 | — | — | US | disclosed |
| US-20220041530-A1 | Method for Preparation of Fluoro Alkylated Compounds by Homogeneous NI Catalysis | LONZA LTD (CH) | 2022-02-10 | — | — | US | disclosed |
| EP-3215476-B1 | METHOD FOR PREPARATION OF FLUORO, CHLORO AND FLUOROCHLORO ALKYLATED COMPOUNDS BY HOMOGENEOUS CATALYSIS | LONZA AG (CH) | 2018-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220041530-A1 | Method for Preparation of Fluoro Alkylated Compounds by Homogeneous NI Catalysis | ABL1, AFF2, NAF1 | HTR1D 3181/4885HSD11B1 899/4885CYP2A6 252/4885 |
| US-11530175-B2 | Method for preparation of fluoro alkylated compounds by homogeneous Ni catalysis | ABL1, AFF2, NAF1 | HTR1D 3181/4885HSD11B1 899/4885CYP2A6 252/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.