Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.38 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.37 |
| ▸ | RECQL | P46063 | 2/20 | 0.37 |
| ▸ | S1PR2 | O95136 | 2/20 | 0.37 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.37 |
| ▸ | S1PR3 | Q99500 | 2/20 | 0.37 |
| ▸ | LPAR2 | Q9HBW0 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | DRD2 | P14416 | 1/20 | 0.35 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | DRD3 | P35462 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR1B | P28222 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9845132 | 0.81 | SIGMAR1 (0.49) | SIGMAR1RECQLMEN1KMT2AALDH1A1 | |
| SCHEMBL19904450 | 0.81 | MEN1 (0.39) | RECQLS1PR2S1PR1S1PR3GAA | |
| SCHEMBL18634962 | 0.78 | ALDH1A1 (0.40) | SKP2RECQLGAAMEN1KMT2A | |
| SCHEMBL9845102 | 0.76 | RECQL (0.49) | SIGMAR1RECQLGAAMEN1KMT2A | |
| SCHEMBL19904403 | 0.76 | ALDH1A1 (0.36) | SKP2RECQLS1PR1GAAMEN1 | |
| SCHEMBL9845131 | 0.76 | RECQL (0.52) | SIGMAR1RECQLGAAMEN1KMT2A | |
| SCHEMBL9845125 | 0.75 | RECQL (0.51) | SIGMAR1RECQLGAAMEN1KMT2A | |
| SCHEMBL22673091 | 0.74 | SKP2 (0.36) | SIGMAR1SKP2S1PR2S1PR1S1PR3 | |
| SCHEMBL24045454 | 0.74 | HRH1 (0.47) | SIGMAR1RECQLALDH1A1DRD2 | |
| SCHEMBL21122862 | 0.74 | ABCB1 (0.46) | SIGMAR1RECQLALDH1A1DRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |