Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.34 |
| ▸ | HRH1 | P35367 | 2/20 | 0.34 |
| ▸ | CCR3 | P51677 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.34 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.34 |
| ▸ | GAA | P10253 | 2/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10260908 | 0.83 | CSNK2A1 (0.34) | PDE4BCSNK2A1FFAR1 | |
| SCHEMBL18634962 | 0.80 | ALDH1A1 (0.40) | ALDH1A1MEN1KMT2AMAPTRECQL | |
| SCHEMBL23731761 | 0.76 | FFAR4 (0.41) | ALDH1A1HRH1FFAR4TSHR | |
| SCHEMBL21122862 | 0.76 | ABCB1 (0.46) | ALDH1A1RECQLHRH1 | |
| SCHEMBL19904683 | 0.76 | SIGMAR1 (0.38) | ALDH1A1MEN1KMT2AMAPTRECQL | |
| SCHEMBL24045454 | 0.76 | HRH1 (0.47) | ALDH1A1RECQLHRH1KCNH2SMN1; SMN2 | |
| SCHEMBL18634973 | 0.74 | HDAC1 (0.44) | MEN1KMT2AHPGDFFAR4KCNH2 | |
| SCHEMBL19904660 | 0.72 | HRH3 (0.46) | MAPTPDE4BKCNH2CRHBPCRHR2 | |
| SCHEMBL22737939 | 0.71 | ATM (0.56) | SMN1; SMN2 | |
| SCHEMBL22693870 | 0.69 | SYK (0.48) | RECQLPDE4BCSNK2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |