Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.38 |
| ▸ | HTR1A | P08908 | 1/20 | 0.37 |
| ▸ | CCR1 | P32246 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | PROKR2 | Q8NFJ6 | 1/20 | 0.35 |
| ▸ | UGCG | Q16739 | 1/20 | 0.35 |
| ▸ | PDCD1 | Q15116 | 1/20 | 0.35 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904551 | 0.99 | HTR1A (0.38) | KMT2ANOTUMHTR1ACCR1TSHR | |
| SCHEMBL19904368 | 0.99 | HTR1A (0.38) | KMT2ANOTUMHTR1ACCR1TSHR | |
| SCHEMBL19904488 | 0.98 | KMT2A (0.38) | KMT2ANOTUMHTR1ACCR1TSHR | |
| SCHEMBL19904542 | 0.94 | UGCG (0.40) | KMT2ANOTUMHTR1ATSHRMAPK1 | |
| SCHEMBL19904389 | 0.94 | UGCG (0.40) | KMT2ANOTUMHTR1ATSHRMAPK1 | |
| SCHEMBL19904455 | 0.92 | KMT2A (0.36) | KMT2ANOTUMHTR1AMAPK1ALDH1A1 | |
| SCHEMBL19904590 | 0.92 | KMT2A (0.36) | KMT2ANOTUMHTR1AMAPK1ALDH1A1 | |
| SCHEMBL19904506 | 0.90 | TRPV1 (0.39) | NOTUMHTR1ATSHRMAPK1USP2 | |
| SCHEMBL19904550 | 0.89 | UGCG (0.35) | NOTUMHTR1ATSHRMAPK1USP2 | |
| SCHEMBL19904561 | 0.89 | MCHR1 (0.36) | HTR1AUGCGHDAC4CHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |