Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCHR1 | Q99705 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | BDKRB1 | P46663 | 5/20 | 0.34 |
| ▸ | CAPN1 | P07384 | 3/20 | 0.34 |
| ▸ | TPSAB1 | Q15661 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | UGCG | Q16739 | 1/20 | 0.34 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.33 |
| ▸ | CCR4 | P51679 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904593 | 0.98 | MCHR1 (0.36) | MCHR1HTR1ABDKRB1CAPN1TPSAB1 | |
| SCHEMBL19904498 | 0.94 | KDM4E (0.37) | HTR1AUGCG | |
| SCHEMBL19904324 | 0.93 | KDM4E (0.37) | HTR1AUGCG | |
| SCHEMBL19904535 | 0.93 | KDM4E (0.37) | HTR1AUGCG | |
| SCHEMBL19904455 | 0.91 | KMT2A (0.36) | MCHR1HTR1ACHRM2 | |
| SCHEMBL19904590 | 0.91 | KMT2A (0.36) | MCHR1HTR1ACHRM2 | |
| SCHEMBL19904389 | 0.90 | UGCG (0.40) | HTR1AUGCGCHRM4 | |
| SCHEMBL19904542 | 0.90 | UGCG (0.40) | HTR1AUGCGCHRM4 | |
| SCHEMBL19904570 | 0.89 | NAMPT (0.33) | HTR1AUGCG | |
| SCHEMBL19904686 | 0.89 | NAMPT (0.33) | HTR1AUGCG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |