Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.41 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | AKT2 | P31751 | 1/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.39 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.38 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.38 |
| ▸ | CALM1 | P0DP23 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5019001 | 0.80 | ST14 (0.48) | HRH1ALDH1A1TSHRPARP10 | |
| SCHEMBL23731761 | 0.77 | FFAR4 (0.41) | HRH1FFAR4ALDH1A1TSHRDDB1 | |
| SCHEMBL24925776 | 0.77 | ALDH1A1 (0.54) | HRH1FFAR4ALDH1A1TSHRPARP10 | |
| SCHEMBL28412906 | 0.76 | HRH1 (0.65) | HRH1ALDH1A1TSHRPARP10 | |
| SCHEMBL16695088 | 0.75 | HRH3 (0.59) | HRH1 | |
| SCHEMBL21122690 | 0.75 | HRH3 (0.50) | — | |
| SCHEMBL16595540 | 0.75 | HRH3 (0.63) | HRH1 | |
| SCHEMBL3678682 | 0.74 | MAOA (0.62) | HRH1HTR2ATAAR1ALDH1A1AKT2 | |
| SCHEMBL6289959 | 0.74 | ST14 (0.45) | HRH1ALDH1A1TSHRPARP10 | |
| SCHEMBL21123290 | 0.74 | HRH3 (0.66) | HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |