Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.40 |
| ▸ | EBP | Q15125 | 2/20 | 0.40 |
| ▸ | DRD2 | P14416 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.40 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.40 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | HRH1 | P35367 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | HTR1D | P28221 | 1/20 | 0.38 |
| ▸ | HTR1B | P28222 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19904416 | 0.89 | ABCB1 (0.44) | SIGMAR1HRH3EBPDRD2SLC6A4 | |
| SCHEMBL19904479 | 0.88 | HRH3 (0.45) | SIGMAR1HRH3EBPDRD2SLC6A4 | |
| SCHEMBL19904510 | 0.88 | ABCB1 (0.43) | SIGMAR1HRH3EBPDRD2SLC6A4 | |
| SCHEMBL16695156 | 0.83 | SIGMAR1 (0.47) | SIGMAR1HRH3DRD2SLC6A4SLC6A3 | |
| SCHEMBL19043653 | 0.81 | SIGMAR1 (0.55) | SIGMAR1HRH3EBPTMEM97ABCB1 | |
| SCHEMBL16695172 | 0.81 | SIGMAR1 (0.44) | SIGMAR1HRH3EBPSLC6A4SLC6A3 | |
| SCHEMBL7999028 | 0.80 | L3MBTL1 (0.51) | SIGMAR1HRH3EBPDRD2SLC6A4 | |
| SCHEMBL23731724 | 0.76 | CSNK2A1 (0.44) | SIGMAR1HRH3DRD2SLC6A4SLC6A3 | |
| SCHEMBL19904406 | 0.74 | HRH3 (0.48) | SIGMAR1HRH3EBPDRD2SLC6A4 | |
| SCHEMBL20382554 | 0.74 | HRH1 (0.53) | SIGMAR1HRH3DRD2SLC6A4SLC6A3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3063141-B1 | N-(1-HYDROXY-3-(PYRROLIDINYL)PROPAN-2-YL)PYRROLIDINE-3-CARBOXAMIDE DERIVATIVES AS GLUCOSYLCERAMIDE SYNTHASE INHIBITORS | BIOMARIN PHARM INC (US) | 2018-02-28 | — | — | EP | disclosed |