Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.40 |
| ▸ | FAAH | O00519 | 6/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 9/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 8/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.34 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17874673 | 0.92 | PRKDC (0.46) | PRKDCFAAHHDAC1PIK3CAUSP2 | |
| SCHEMBL19905441 | 0.91 | PRKDC (0.44) | PRKDCFAAHUSP2CYP1A2CYP3A4 | |
| SCHEMBL19905491 | 0.89 | PRKDC (0.44) | PRKDCFAAH | |
| SCHEMBL19905365 | 0.89 | PRKDC (0.41) | PRKDCFAAH | |
| SCHEMBL19905199 | 0.88 | PRKDC (0.38) | PRKDCFAAHHDAC1PIK3CAUSP2 | |
| SCHEMBL19905448 | 0.88 | FAAH (0.47) | PRKDCFAAHCYP1A2CYP3A4CYP2D6 | |
| SCHEMBL19905258 | 0.83 | PRKDC (0.37) | PRKDCFAAH | |
| SCHEMBL17874675 | 0.83 | PRKDC (0.50) | PRKDCFAAHUSP2CYP1A2CYP3A4 | |
| SCHEMBL15473153 | 0.83 | PRKDC (0.50) | PRKDCFAAHUSP2CYP1A2CYP3A4 | |
| SCHEMBL19355626 | 0.83 | PRKDC (0.44) | PRKDCFAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |