Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.37 |
| ▸ | FAAH | O00519 | 10/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.32 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.31 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | XIAP | P98170 | 1/20 | 0.31 |
| ▸ | BIRC2 | Q13490 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15473150 | 0.93 | PRKDC (0.42) | PRKDCFAAHMAPTIRAK4ABL1 | |
| SCHEMBL17874678 | 0.93 | PRKDC (0.42) | PRKDCFAAHMAPTIRAK4ABL1 | |
| SCHEMBL19905294 | 0.91 | ABL1 (0.40) | PRKDCFAAHABL1BCR | |
| SCHEMBL19905263 | 0.85 | FAAH (0.33) | FAAHMAPTIRAK4ABL1BCR | |
| SCHEMBL17874676 | 0.84 | ABL1 (0.41) | PRKDCFAAHABL1BCR | |
| SCHEMBL19905481 | 0.83 | PRKDC (0.40) | PRKDCFAAH | |
| SCHEMBL19905365 | 0.83 | PRKDC (0.41) | PRKDCFAAH | |
| SCHEMBL19905448 | 0.82 | FAAH (0.47) | PRKDCFAAHMAPT | |
| SCHEMBL19905491 | 0.82 | PRKDC (0.44) | PRKDCFAAHMAPTABL1BCR | |
| SCHEMBL19905441 | 0.81 | PRKDC (0.44) | PRKDCFAAHABL1BCR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3057959-B1 | DNA-PK INHIBITORS | VERTEX PHARMA (US) | 2018-02-28 | — | — | EP | disclosed |