Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | MAPT | P10636 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23095903 | 0.84 | ALDH1A1 (0.46) | ALDH1A1LMNARAPGEF4GAAPOLB | |
| SCHEMBL16301229 | 0.80 | LMNA (0.50) | ALDH1A1LMNARAPGEF4GAAPOLB | |
| SCHEMBL1645546 | 0.79 | TSHR (0.60) | ALDH1A1LMNARAPGEF4GAAPOLB | |
| SCHEMBL22791495 | 0.76 | GAA (0.58) | ALDH1A1LMNARAPGEF4GAAPOLB | |
| SCHEMBL21131436 | 0.74 | RAPGEF4 (0.47) | ALDH1A1LMNARAPGEF4GAAPOLB | |
| SCHEMBL20673500 | 0.74 | FERMT2 (0.50) | ALDH1A1LMNARAPGEF4GAAPOLB | |
| SCHEMBL11698648 | 0.73 | GAA (0.47) | ALDH1A1LMNARAPGEF4GAAPOLB | |
| SCHEMBL14318813 | 0.72 | MAPT (0.61) | ALDH1A1LMNAGAAMAPTMEN1 | |
| SCHEMBL31544492 | 0.72 | MAPT (0.61) | ALDH1A1LMNAGAAMAPTMEN1 | |
| SCHEMBL23095948 | 0.72 | MAPT (0.39) | ALDH1A1LMNAGAAMAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2684880-B1 | DISPIROPYRROLIDINE DERIVATIVE | DAIICHI SANKYO CO LTD (JP) | 2018-02-28 | — | — | EP | disclosed |