SCHEMBL1990768

SCHEMBL1990768

CC(=O)Nc1nonc1NC(=O)c1ccc(S(C)(=O)=O)cc1Cl

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 1/20 0.52
GPR27 Q9NS67 1/20 0.52
SMO Q99835 3/20 0.52
MAPT P10636 3/20 0.51
CYP2C19 P33261 2/20 0.51
MEN1 O00255 1/20 0.51
ALDH1A1 P00352 1/20 0.51
PPARG P37231 1/20 0.51
KMT2A Q03164 1/20 0.51
NCOA2 Q15596 1/20 0.51
NCOA1 Q15788 1/20 0.51
NPSR1 Q6W5P4 1/20 0.51
RXFP1 Q9HBX9 1/20 0.51
RAB9A P51151 2/20 0.50
GAA P10253 1/20 0.50
USP28 Q96RU2 9/20 0.48
ALB P02768 1/20 0.48
HTR1A P08908 1/20 0.48
SLC6A2 P23975 1/20 0.48
PDE4A P27815 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1457879 0.83 MAPT (0.56) AVPR2GPR27SMOMAPTCYP2C19
SCHEMBL26412112 0.74 AVPR2 (0.58) AVPR2GPR27SMOMAPTCYP2C19
SCHEMBL15774277 0.73 MEN1 (0.54) AVPR2GPR27SMOMAPTCYP2C19
SCHEMBL12724094 0.72 LMNA (0.59) AVPR2GPR27SMOMAPTCYP2C19
SCHEMBL14551128 0.72 AVPR2 (0.71) AVPR2GPR27SMOMAPTCYP2C19
SCHEMBL28899120 0.72 SMO (0.68) AVPR2GPR27SMOMAPTCYP2C19
SCHEMBL15095560 0.71 CA1 (0.74) MAPTMEN1ALDH1A1KMT2ARAB9A
SCHEMBL28335013 0.71 USP28 (0.54) AVPR2GPR27SMOMAPTCYP2C19
SCHEMBL27418868 0.71 AVPR2 (0.52) AVPR2GPR27SMOMAPTCYP2C19
SCHEMBL28608861 0.71 AVPR2 (0.55) AVPR2GPR27SMOMAPTCYP2C19

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8288316-B2 N-(1,2,5-oxadiazol-3-yl)benzamides and their use as herbicides BAYER CROPSCIENCE AG (DE) 2012-10-16 US disclosed
US-20110152084-A1 N-(1,2,5-OXADIAZOL-3-YL)BENZAMIDES AND THEIR USE AS HERBICIDES BAYER CROPSCIENCE AG (DE) 2011-06-23 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20110152084-A1 N-(1,2,5-OXADIAZOL-3-YL)BENZAMIDES AND THEIR USE AS HERBICIDES AOX1, CBR3, ZYX AVPR2 2416/4885GPR27 3571/4885SMO 2799/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.