Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALK | Q9UM73 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.39 |
| ▸ | NOX4 | Q9NPH5 | 1/20 | 0.38 |
| ▸ | UCHL3 | P15374 | 2/20 | 0.36 |
| ▸ | UCHL1 | P09936 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601466 | 0.87 | ALK (0.41) | ALKKMT2AMEN1POLBP2RX7 | |
| SCHEMBL19908214 | 0.85 | TRAP1 (0.38) | ALKKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL14387485 | 0.82 | KMT2A (0.39) | ALKKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL19908483 | 0.82 | ALK (0.51) | ALKKMT2AMEN1POLBSMN1; SMN2 | |
| SCHEMBL19908238 | 0.80 | ALK (0.63) | ALKP2RX7NOX4 | |
| SCHEMBL19908280 | 0.78 | ALK (0.41) | ALKSMN1; SMN2GAA | |
| SCHEMBL19908479 | 0.74 | ALK (0.43) | ALKP2RX7 | |
| SCHEMBL1601266 | 0.74 | TRAP1 (0.46) | ALKKMT2AMEN1POLBP2RX7 | |
| SCHEMBL19908302 | 0.74 | EDNRB (0.47) | ALKP2RX7 | |
| SCHEMBL14387480 | 0.74 | ALK (0.37) | ALKP2RX7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |