Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 1/20 | 0.47 |
| ▸ | EDNRA | P25101 | 1/20 | 0.47 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.41 |
| ▸ | C5AR1 | P21730 | 2/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.37 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.37 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.37 |
| ▸ | HSD17B13 | Q7Z5P4 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.36 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.36 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.36 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.36 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601474 | 0.88 | EDNRB (0.43) | EDNRBEDNRAP2RX7HTR2CHTR2B | |
| SCHEMBL19908261 | 0.82 | TRPC5 (0.44) | P2RX7HTR2CHTR2BTRPC5C5AR1 | |
| SCHEMBL14387480 | 0.80 | ALK (0.37) | EDNRBEDNRAP2RX7TRPC5C5AR1 | |
| SCHEMBL19908479 | 0.79 | ALK (0.43) | EDNRBEDNRAP2RX7TRPC5CHRM5 | |
| SCHEMBL14387485 | 0.78 | KMT2A (0.39) | EDNRBEDNRATRPC5BRD4ALK | |
| SCHEMBL19908280 | 0.76 | ALK (0.41) | EDNRBEDNRAALK | |
| SCHEMBL19908214 | 0.74 | TRAP1 (0.38) | ALKADORA2A | |
| SCHEMBL19908258 | 0.74 | ALK (0.43) | P2RX7ALK | |
| SCHEMBL19908278 | 0.73 | SCN9A (0.42) | HTR2CHTR2BALK | |
| SCHEMBL19908483 | 0.73 | ALK (0.51) | EDNRBEDNRAALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |