Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | NNMT | P40261 | 1/20 | 0.51 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.51 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.49 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.49 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.49 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.49 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.49 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.48 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 7/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 7/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8389254 | 0.86 | PIK3C3 (0.52) | NNMTKCNH2TGFBR1RIPK1MKNK1 | |
| SCHEMBL8387765 | 0.81 | CYP11B2 (0.55) | KCNH2BMPR1BBMPR1AACVRL1ACVR1 | |
| SCHEMBL1602736 | 0.80 | BMPR1B (0.51) | POLBKCNH2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL1601053 | 0.78 | POLB (0.55) | POLBKCNH2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL22226400 | 0.76 | NNMT (0.64) | POLBNNMTHPGDCYP11B2 | |
| SCHEMBL1601082 | 0.76 | ALK (0.63) | POLBKCNH2ACVR1RIPK1MKNK1 | |
| SCHEMBL20449050 | 0.74 | POLB (0.86) | POLBHPGDCHKA | |
| SCHEMBL1601057 | 0.74 | POLB (0.47) | POLBKCNH2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL1601049 | 0.74 | ALK (0.47) | POLBKCNH2BMPR1BBMPR1AACVRL1 | |
| SCHEMBL24319038 | 0.73 | KCNH2 (0.67) | POLBKCNH2BMPR1BBMPR1AACVRL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |