Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS1 | P29475 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | HPGD | P15428 | 2/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | CRBN | Q96SW2 | 2/20 | 0.40 |
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | STAT3 | P40763 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GPR6 | P46095 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1601376 | 0.85 | NOS1 (0.48) | NOS1ALDH1A1HPGDRAB9AKMT2A | |
| SCHEMBL19908281 | 0.82 | ALDH1A1 (0.45) | ALDH1A1RAB9ASMN1; SMN2GRM5HSD17B10 | |
| SCHEMBL1601639 | 0.80 | NOS1 (0.53) | NOS1ALDH1A1HPGDNPC1RAB9A | |
| SCHEMBL1600998 | 0.80 | AVPR2 (0.49) | NOS1POLBSTAT3ALKHSD17B10 | |
| SCHEMBL3601421 | 0.80 | NOS1 (0.49) | NOS1ALDH1A1HPGDCRBNALK | |
| SCHEMBL3601417 | 0.79 | ALK (0.49) | NOS1ALK | |
| SCHEMBL1601622 | 0.79 | ALK (0.47) | NOS1NPC1RAB9AKMT2ASMN1; SMN2 | |
| SCHEMBL1601053 | 0.78 | POLB (0.55) | ALDH1A1NPC1GRM5POLBALK | |
| SCHEMBL14387373 | 0.78 | ALK (0.38) | ALDH1A1ALKGPR6 | |
| SCHEMBL1601615 | 0.73 | CAMK2D (0.46) | HPGDALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2091951-B1 | PYRIDO[2,3-B]PYRAZINE AND [1,8]-NAPHTHYRIDINE DERIVATIVES AS ALK AND C-MET INHIBITORS | CEPHALON INC (US) | 2018-02-28 | — | — | EP | disclosed |