Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 4/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.42 |
| ▸ | ESR1 | P03372 | 2/20 | 0.41 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.41 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.41 |
| ▸ | TACR2 | P21452 | 2/20 | 0.41 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.41 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SHBG | P04278 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | HSPD1 | P10809 | 1/20 | 0.41 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HSPE1 | P61604 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20937692 | 1.00 | TDP1 (0.50) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL19909082 | 1.00 | TDP1 (0.50) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL19909213 | 0.98 | TDP1 (0.52) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL9921224 | 0.92 | TDP1 (0.44) | TDP1L3MBTL1CYP3A4TP53 | |
| SCHEMBL4410512 | 0.92 | NOS1 (0.42) | TDP1L3MBTL1CYP3A4 | |
| Formic Acid SCHEMBL28260239 | 0.90 | TDP1 (0.42) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL27563659 | 0.88 | TDP1 (0.57) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL27733869 | 0.86 | TDP1 (0.59) | TDP1L3MBTL1PTGS2CYP3A4ESR1 | |
| SCHEMBL4289948 | 0.84 | TKT (0.44) | CYP3A4 | |
| Hydrochloric Acid SCHEMBL28015977 | 0.84 | TDP1 (0.57) | TDP1L3MBTL1PTGS2CYP3A4ESR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10888563-B2 | Fused heterotricyclic organic compounds, pharmaceutical compositions, and medical uses thereof | ALEVERE MEDICAL CORPORATION (US) | 2021-01-12 | — | — | US | disclosed |
| US-20190117656-A1 | FUSED HETEROTRICYCLIC ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF | ALEVERE MEDICAL CORPORATION | 2019-04-25 | — | — | US | disclosed |
| EP-2935248-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-02-28 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190117656-A1 | FUSED HETEROTRICYCLIC ORGANIC COMPOUNDS, PHARMACEUTICAL COMPOSITIONS, AND MEDICAL USES THEREOF | FABP4, HSD17B4, LIPC | TDP1 1153/4885L3MBTL1 4837/4885PTGS2 1093/4885 |
| US-10888563-B2 | Fused heterotricyclic organic compounds, pharmaceutical compositions, and medical uses thereof | FABP4, HSD17B4, LIPC | TDP1 1153/4885L3MBTL1 4837/4885PTGS2 1093/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.