Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MAPT | P10636 | 3/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.46 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | EGFR | P00533 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALPG | P10696 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24000004 | 0.85 | EGFR (0.53) | HCAR3MEN1KMT2AMAPTLMNA | |
| SCHEMBL6391527 | 0.79 | HCAR3 (0.50) | HCAR3MAPTTSHRRAB9AEGFR | |
| SCHEMBL21258996 | 0.78 | HCAR3 (0.56) | HCAR3MEN1KMT2AMAPTLMNA | |
| SCHEMBL83157 | 0.78 | HCAR3 (0.56) | HCAR3MEN1KMT2AMAPTLMNA | |
| SCHEMBL27652089 | 0.75 | FABP1 (0.54) | MEN1KMT2AMAPTLMNARAB9A | |
| SCHEMBL31532396 | 0.74 | ALDH1A1 (0.60) | HCAR3MEN1KMT2AMAPTLMNA | |
| SCHEMBL21258720 | 0.74 | HCAR3 (0.56) | HCAR3MEN1KMT2AMAPTLMNA | |
| SCHEMBL2280918 | 0.74 | ALDH1A1 (0.60) | HCAR3MEN1KMT2AMAPTLMNA | |
| SCHEMBL670916 | 0.74 | HCAR3 (0.56) | HCAR3MEN1KMT2AMAPTLMNA | |
| SCHEMBL913981 | 0.74 | HCAR3 (0.56) | HCAR3MEN1KMT2AMAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2935248-B1 | COMPOUNDS AND METHODS FOR KINASE MODULATION, AND INDICATIONS THEREFOR | PLEXXIKON INC (US) | 2018-02-28 | — | — | EP | disclosed |