Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR3 | P49019 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 4/20 | 0.53 |
| ▸ | MEN1 | O00255 | 4/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | ALPG | P10696 | 1/20 | 0.47 |
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | IKBKB | O14920 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22938770 | 0.88 | HCAR3 (0.42) | HCAR3MAPTMEN1KMT2ALMNA | |
| SCHEMBL21666862 | 0.83 | EDNRA (0.36) | HCAR3MAPTMEN1KMT2ALMNA | |
| SCHEMBL22788044 | 0.79 | RAB9A (0.59) | MAPTRAB9AKDM4ECDK2NPC1 | |
| SCHEMBL31532396 | 0.76 | ALDH1A1 (0.60) | HCAR3MAPTMEN1KMT2ALMNA | |
| SCHEMBL913981 | 0.76 | HCAR3 (0.56) | HCAR3MAPTMEN1KMT2ALMNA | |
| SCHEMBL21258720 | 0.76 | HCAR3 (0.56) | HCAR3MAPTMEN1KMT2ALMNA | |
| SCHEMBL2280918 | 0.76 | ALDH1A1 (0.60) | HCAR3MAPTMEN1KMT2ALMNA | |
| SCHEMBL21258996 | 0.76 | HCAR3 (0.56) | HCAR3MAPTMEN1KMT2ALMNA | |
| SCHEMBL83157 | 0.76 | HCAR3 (0.56) | HCAR3MAPTMEN1KMT2ALMNA | |
| SCHEMBL28513546 | 0.75 | RAB9A (0.62) | MEN1KMT2ALMNARAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2606052-A1 | NICOTINIC RECEPTOR COMPOUNDS | Research Triangle Institute (US) | 2013-06-26 | — | — | EP | disclosed |
| WO-2012024615-A1 | NICOTINIC RECEPTOR COMPOUNDS | RESEARCH TRIANGLE INSTITUTE (US) | 2012-02-23 | — | — | WO | disclosed |
| EP-2268143-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | Forest Laboratories Holdings Limited (BM) | 2011-01-05 | — | — | EP | disclosed |
| WO-2009117676-A2 | NOVEL PIPERIDINE DERIVATIVES AS INHIBITORS OF STEAROYL-COA DESATURASE | FOREST LABORATORIES HOLDINGS LIMITED (BM) | 2009-09-24 | — | — | WO | disclosed |