Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 3/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.34 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | PGR | P06401 | 3/20 | 0.34 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | HTR1A | P08908 | 1/20 | 0.31 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.31 |
| ▸ | HTR1D | P28221 | 1/20 | 0.31 |
| ▸ | HTR1B | P28222 | 1/20 | 0.31 |
| ▸ | HTR7 | P34969 | 1/20 | 0.31 |
| ▸ | HTR3A | P46098 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16709826 | 0.81 | POLB (0.44) | POLBMAPTTP53NR1H4 | |
| SCHEMBL21638399 | 0.79 | MAPT (0.51) | POLBMAPTTP53SMN1; SMN2KDM4E | |
| SCHEMBL24156660 | 0.73 | TP53 (0.38) | MAPTADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL12918327 | 0.71 | MAOA (0.42) | POLBMAPTADRA2AADRA2BPGR | |
| SCHEMBL21574193 | 0.71 | MAPT (0.44) | POLBMAPTPGRNR3C2TP53 | |
| SCHEMBL23889226 | 0.66 | SETD7 (0.45) | MAPTADRA2AADRA2BADRA1AMEN1 | |
| SCHEMBL12178135 | 0.65 | PARP1 (0.54) | POLBMAPTADRA2AADRA2BADRA2C | |
| SCHEMBL13978611 | 0.64 | ESR2 (0.73) | ADRA2AADRA2BADRA2CADRA1APGR | |
| SCHEMBL23402885 | 0.62 | TDP2 (0.39) | MAPTTP53MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL23231070 | 0.60 | KMT2A (0.42) | POLBADRA2AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3065738-B1 | COMPOSITIONS AND METHODS FOR MODULATING FARNESOID X RECEPTORS | NOVARTIS AG (CH) | 2018-02-28 | — | — | EP | disclosed |