Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | DRD2 | P14416 | 5/20 | 0.37 |
| ▸ | DRD4 | P21917 | 5/20 | 0.37 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.36 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.36 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.34 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | F7 | P08709 | 1/20 | 0.34 |
| ▸ | F3 | P13726 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | BRD4 | O60885 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29766649 | 0.84 | ADRA2A (0.36) | TP53DRD2DRD4ADRA2AADRA2B | |
| SCHEMBL25897315 | 0.84 | ADRA2A (0.36) | TP53DRD2DRD4ADRA2AADRA2B | |
| SCHEMBL25897326 | 0.84 | HIF1A (0.36) | TP53DRD2DRD4HIF1AKMT2A | |
| SCHEMBL26967792 | 0.79 | MEN1 (0.41) | TP53KMT2AMEN1CYP1A2CYP2C9 | |
| SCHEMBL19910346 | 0.73 | POLB (0.34) | TP53ADRA2AADRA2BADRA2CADRA1A | |
| SCHEMBL25897321 | 0.72 | MEN1 (0.39) | TP53KMT2AMEN1MAPTKDM4E | |
| SCHEMBL27107113 | 0.72 | HIF1A (0.37) | DRD2DRD4HIF1AKMT2AMEN1 | |
| SCHEMBL24156933 | 0.71 | DRD2 (0.34) | DRD2DRD4HIF1AKMT2AMEN1 | |
| SCHEMBL16709826 | 0.68 | POLB (0.44) | TP53MAPT | |
| SCHEMBL9537880 | 0.67 | MAPT (0.51) | TP53KMT2AMEN1CYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024042361-A1 | TYK2 INHIBITORS AND USES THEREOF | SUDO BIOSCIENCES LIMITED (GB) | 2024-02-29 | — | — | WO | disclosed |
| WO-2021259208-A1 | TYK-2 INHIBITOR | BEIGENE, LTD. (KY) | 2021-12-30 | — | — | WO | disclosed |