Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 17/20 | 0.68 |
| ▸ | RIPK1 | Q13546 | 3/20 | 0.62 |
| ▸ | RIPK3 | Q9Y572 | 3/20 | 0.62 |
| ▸ | AURKA | O14965 | 2/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.62 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.62 |
| ▸ | PLK4 | O00444 | 1/20 | 0.62 |
| ▸ | GAK | O14976 | 1/20 | 0.62 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.62 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | CA12 | O43570 | 1/20 | 0.62 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.62 |
| ▸ | JAK2 | O60674 | 1/20 | 0.62 |
| ▸ | STK16 | O75716 | 1/20 | 0.62 |
| ▸ | STK10 | O94804 | 1/20 | 0.62 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.62 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | CA1 | P00915 | 1/20 | 0.62 |
| ▸ | CA2 | P00918 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17261018 | 0.88 | KDR (0.79) | KDRRIPK1RIPK3AURKAABCB11 | |
| SCHEMBL19913010 | 0.87 | KDR (0.90) | KDRRIPK1RIPK3AURKACYP3A4 | |
| SCHEMBL23587676 | 0.85 | KDR (0.66) | KDRRIPK1RIPK3AURKAABCB11 | |
| SCHEMBL4816559 | 0.84 | KDR (0.62) | KDRRIPK1RIPK3AURKAABCB11 | |
| SCHEMBL13980585 | 0.84 | KDR (0.70) | KDRRIPK1RIPK3AURKAABCB11 | |
| SCHEMBL4814390 | 0.82 | KDR (0.86) | KDRRIPK1RIPK3AURKACYP3A4 | |
| SCHEMBL4817087 | 0.81 | KDR (1.00) | KDRRIPK1RIPK3AURKACYP3A4 | |
| SCHEMBL23587690 | 0.80 | KDR (0.62) | KDRRIPK1RIPK3AURKAABCB11 | |
| SCHEMBL17260962 | 0.80 | KDR (0.78) | KDRRIPK1RIPK3AURKAABCB11 | |
| SCHEMBL18793228 | 0.80 | KDR (0.72) | KDRRIPK1RIPK3AURKAMLKL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180057465-A1 | Inhibitors of Necroptosis | CATALYST THERAPEUTICS PTY LTD (AU) | 2018-03-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180057465-A1 | Inhibitors of Necroptosis | RIPK3, RIPK1, AIFM1 | KDR 4209/4885RIPK1 2/4885RIPK3 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.